Effect of dopamine combined with norepinephrine on serum levels of procalcitonin and cardiac troponin I in patients with septic shock

LI Yanfei; YANG Jia; ZHU Handong; JIANG Feng

doi:10.3969/j.issn.1671-6450.2016.10.012

Abstract：Objective To observe the effect of dopamine combined with norepinephrine on serum levels of procalcito-nin and troponin I (cTn1) in patients with septic shock.Methods One hundred cases of patients with septic shock were ad-mitted from February 2014 to February 2016 in department of general medicine, Seventh hospital of Wuhan, they were divided into observation group and control group by randomly, 50 cases in each group.The control group was treated with simple dopa-mine, and the observation group was treated with the addition of noradrenaline on the basis of the control group.The changes of blood pressure, NT-proBNP(N terminal B type natriuretic peptide), LVEF(left ventricular ejection fraction), serum levels of PCT ( procalcitonin) , cTn1 ( cardiac troponinⅠ) , CRP ( C reactive protein) , TNF-α( tumor necrosis factor α) were ob-served before and after treatment in two groups, and adverse reactions in the course of treatment were observed.Results After treatment, the total efficiency of the observation group was significantly higher than the control group (80.0% vs.62.0%,χ2 =3.933, P =0.047); LVEF, diastolic blood pressure was significantly higher than that of control group [(67.83 ± 7.45) mmHg vs.(62.05 ±6.93) mmHg, (59.84 ±8.30)%vs.(43.94 ±6.01)%, t =4.016, t =10.971, P <0.01], NT-proBNP was significantly lower than the control group [(1 084.34 ±213.93) ng/L vs.(1 458.29 ±275.83) ng/L, t =7.575, P <0.01];PCT, cTn1, CRP, TNF-αlevels were significantly lower than the control group [(0.95 ±0.14) μg/L vs.(2.63 ±0.47) g/L, (1.74 ±0.25) μg/L vs.(3.09 ±0.51) μg/L, (5.12 ±0.79) mg/L vs.(6.95 ±1.14) mg/L, (75.32 ±18.93) ng/L vs.(146.87 ±23.16) ng/L, t =24.223, t =16.806, t =9.329, t =16.914, P <0.05];adverse reaction the rate is lower than the control group (14 .0%vs.32.0%,χ2 =4.573, P =0.032).Conclusion Septic shock patients were treated with dopamine combined with norepinephrine, the effect is significant, it is worthy of application and pro-motion.