Ambroxol adjuvant therapy with pulmonary function and blood gas indexes in patients with pulmonary infection in patients with chronic obstructive pulmonary disease

LIU Bo; ZHANG Rui; PENG Wei; LU Yang; ZHANG Xiaoyu; YOU Jihui

doi:10.3969/j.issn.1671-6450.2016.10.008

Abstract：Objective To observe of ambroxol hydrochloride in treatment of chronic obstructive pulmonary disease ( COPD) patients with pulmonary infection and its effect on lung function and blood gas index.Methods Ninety-two cases of patients with COPD and pulmonary infection were selected, which were treated in hospital from January 2014 to January 2016, and they were divided into the observation group (46 cases) and control group (46 cases).The patients of control group were treated with conventional treatment, including oxygen, antibiotics, bronchodilators relieve, correct electrolyte imbalance, maintain the acid base balance, cough expectorant, asthma, enhance rehydration and so on.On the basis of the control group, the patients of observation group were treated with ambroxol hydrochloride.The patients of two groups were all treated with continued seven days.Compare the clinical efficacy, clinical symptoms improved time and changes of thelevels of pulmonary infection score ( CPIS) , acute physiology and chronic health evaluationⅡ( APACHEⅡ) , lung function and blood gas of two groups.Results The total efficiency of the observation group was significantly higher than the control group ( 91.3% vs. 73.9% χ2 =4.842, P =0.028);after treatment, the patients in the observation group were cough, expectoration, pulmonary rales, shortness of breath response time and hospitalization time were significantly lower than the control group ( t =164.197, t =8.209, t =2.872, t =6.925, P =0.000, P =0.000, P =0.003, P =0.000);CPIS, APACHE score were decreased, and the observation group was significantly lower than the control group ( t =20.464, t =12.765, P =0.000, P =0.000);the observation group FVC, FEV1 , FEV1%, PaO2 , PaCO2 , pH values improved significantly better than control group ( t =9.276, t =7.633, t =7.302, t =6.726, t =3.491, t =5.416, all P <0.01);the observation group occurred during the treatment of stomach discomfort in 2 cases, 1 cases of dry mouth symptoms improved after symptomatic treatment;the control group had no adverse reaction, the incidence of adverse reactions of the 2 groups were compared, no difference Statistical sig-nificance (χ2 =2.225, P =0.136).Conclusion Ambroxol hydrochloride for the treatment of COPD with pulmonary infec-tion curative effect, can significantly improve the pulmonary function and blood gas indexes, life quality, safe and effective.