The efef ct of ticagrelor in emergency int erventional therapy for acut e ST segment elevait on myocardial infarction
NIU Hongxia
ZHU Xiaowen
KANG Feng
CHEN Shixuan
CHEN Xi
HAN Yonghua
Abstract：Objective To observe efficacy and safety of ticagrelor in patients with acute ST elevation myocardial in-farction (STEMI) undergoing emergency percutaneous coronary intervention (PCI).Methods Totally 108 patients, who were from the emergency department of electric teaching hospital of capital medical university during 2014 Feb to 2015 Dec, they were selected as research subjects.All the patients were randomly divided into treatment group and control group.Pa-tients in the treatment group were given aspirin 300 mg ticagrelor 180 mg before PIC, and were given ticagrelor 180 mg only after PIC.Patients in the control group were given aspirin 300 mg clopidogrel 600 mg before PIC, and they were given clopi-dogrel 75mg only after PCI.Thrombolysis in myocardial infarction (TIMI), no reflow events, platelet count, platelet inhibi-tion rate, major adverse cardiovascular events and bleeding events.Results The treatment group TIMI flow grade was signifi-cantly higher than the control group, no flow rate was significantly lower than the control group ( Z =6.022,χ2 =4.031, P =0.049, P =0.045);the treatment group platelet inhibition rate was significantly higher than control group ( t =3.210, P =0.000) .Adverse cardiac events in treatment group after 1 months was significantly lower than the control group (χ2 =4.412, P =0.038), the 2 groups had no statistically significant difference in bleeding events (χ2 =1.352, P =0.254).Conclusion Antiplatelet therapy of ticagrelor on patients with STEMI undergoing PIC has good efficacy and safety.
Keywords：ST segment elevated myocardial infarctionPercutaneous coronary interventionAntiplatelet therapyTi-cagrelor
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 994-997 )