Effect of spleen polypeptide combined with radiotherapy on the short-term efficacy of advanced esophageal carcinoma and its influence on the level of T lymphocyte subsets
SONG Xianlu
SHI Xingyuan
WEN Yuefeng
ZHOU Tongchong
Abstract：Objective To observe the short-term curative effect of spleen polypeptide combined with radiotherapy on advanced esophageal carcinoma and its effect on the level of T lymphocyte subsets .Methods From July 2011 to July 2015 , in the Department of radiotherapy; Affiliated Tumor Hospital of Guangzhou Medical College , 79 cases of advanced esophageal carcinoma hospitalized patients were enrolled as the research object , according to the different treatment method , they were di-vided into control group ( n =38) and observation group ( n =41).The control group was treated with radiotherapy only , and the observation group was treated with Lienal Polypeptide Injection on the basis of the observation group .Compare the clinical efficacy, quality of life and the level of T cell subsets in the 2 groups.Results (1) The clinical remission rate and the clinical control rate (DCR) of observation group (RR) were 63.41%and 85.37%, 47.37%and 76.32%, which were higher than the control group, the difference was statistically significant (χ2 =5.291,χ2 =3.783;P =0.029, P =0.040);(2) After treatment, the observation group of normal white blood cells , KPS score increased, esophageal pain relief , im-proved appetite and body weight increased the proportion of patients were significantly higher than those in control group (χ2 =8 .928 ,χ2 =11 .938 ,χ2 =6 .672 ,χ2 =5 .383 ,χ2 =14 .599;P =0 .018 , P =0 .008 , P =0 .027 , P =0 .032 , P =0 .007 );(3) Compared with before treatment , after treatment, the patients in the observation group CD3 +, CD4 +and the level of CD4 +/CD8 +increased significantly, CD8 +decreased significantly ( t =5.102,6.019,7.187,4.334, P =0.028,0.022, 0.017,0.032), while the control group showed no significant change ( P >0.05); patients in the observation group after treatment the indicators were better than the control group ( t =3.309, t =4.403, t =3.872, t =5.182;P =0.042, P =0.031, P =0.038, P =0.027).Conclusion Spleen polypeptide combined with radiotherapy in the treatment of advanced e -sophageal cancer has a significant clinical effect , and it may play a role by changing the level of T lymphocyte subsets in pa-tients of advanced esophageal cancer .
Keywords：Spleen polypeptideRadiotherapyEsophageal cancerEfficacyT lymphocyte subsets
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 939-942 )