The relationship of the levels of FT3, FT4, TSH and atherosclerosis related factors of patients with hyperthyroidism
ZHANG Zhongzhi
ZHANG Hongmei
FU Xiaoling
Abstract：Objective To investigate the relationship of the levels of FT 3 , FT4 , TSH and atherosclerosis related fac-tors of patients with hyperthyroidism .Methods One hundred and twenty cases of hyperthyroidism patients and 100 healthy volunteers were selected from January 2015 to December 2015 .The transcranial doppler ultrasound of carotid arteries of two groups were analyzed with cranial artery stenosis , carotid stenosis and carotid artery plaque generation situation .The levels of FT3 , FT4 , TSH, total cholesterol ( TC) , triglyceride ( TG) , low density protein ( LDL-C) , high density protein ( HDL-C) , asymmetric arginine methyl (ADMA), carotid intima media thickness (IMT), C reactive protein (CRP), thromboxane B2 (TXB2), endothelin (ET-1) and nitric oxide (NO) were determined.The relationship of the levels of FT3, FT4, TSH and atherosclerosis related factors were analyzed .Results The patients with hyperthyroidism cranial artery stenosis , carotid steno-sis and carotid artery plaque incidence were significantly higher than control groups (χ2 =93.555, χ2 =47.324, χ2 =14.379;P =0.000, P =0.000, P =0.000).The levels of FT3, FT4, TG, LDL-C, IMT, ADMA, CRP, TXB2 of Hyper-thyroidism were higher than control groups ( t =69.634, t =100.183, t =49.204, t =21.817, t =13.237, t =11.127, t =-26.482, t =-32.853, t =-31.536, t =-16.169;P =0.000, P =0.000, P =0.000, P =0.000, P =0.000, P =0 .000, P =0.000, P =0.000, P =0.000, P =0.000).The FT3, FT4 were positively correlated with ADMA, IMT, CRP, TXB2 ( r =0.322, r =0.302, r =0.314, r =0.327, r =0.305, r =0.323, r =0.302, r =0.336;P =0.000, P =0.000, P =0.000, P =0.000, P =0.000, P =0.000, P =0.000, P =0.000), and was negatively correlated with NO after Pear-son Univariate analysis ( r =-0.309, r =-0.325;P =0.000, P =0.000), the TSH were negative correlation with AD-MA, TXB2( r =-0.348, r =-0.319;P =0.000, P =0.000), and was positively correlated with LDL-C and NO ( r =0.326, r =0.304;P =0.000, P =0.000), with the index showed no correlation ( P >0.05).After Logistic multivariate revealed that serum TSH in patients with hyperthyroidism , LDL-C,ADMA, CRP, TXB2 is an independent risk factor for ather-osclerosis, and atherosclerosis is NO protection factor .Conclusion Hyperthyroidism can affect the body's lipid metabolism and promote the secretion of inflammatory cytokines , promote the body atherosclerosis changes caused by atherosclerosis is an independent risk factor .
Keywords：HyperthyroidismFree triiodothyronineFour iodine thyroxineThyroid stimulating hormoneAthero-sclerosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 926-930 )