Effect of Yiqiyangyinhuoxuetongluo decoction on clinical and inflammatory factors in stage IV diabetic nephropathy patients
ZHANG Jianghua
BAI Lu
ZHAO Wenhong
XING Xiaojing
XIE Tian
Abstract：Objective To observe the effect of Yiqiyangyinhuoxuetongluo decoction on clinical curative effect and in-fluence of inflammatory factors in diabetic nephropathy ( DN) patients with stage IV .Methods From January 2014 to January 2016 , 60 cases of DN patients in Shijiazhuang Hospital of traditional Chinese medicine were selected as the research object . The random number table method is divided into 2 groups of research group and control group , patients treatment with diabetes education , low salt low fat low sugar diet , moderate exercise , basic medicine control blood sugar , blood pressure standards . Patients in control group were treated with irbesartan tablets for oral treatment , research group based on syndrome differentia-tion plus oral medicine , treatment for 3 months, compared with two groups before and after treatment and between the two groups of the clinical efficacy, 24h urinary total protein (24h UTP), SCr, BUN and inflammatory factors.Results The study group total effective rate was 86.7%, which was higher than the control group 56.7%(χ2 =6.975, P <0.05).Compared with before treatment, two groups of 24h UTP, serum blood urea nitrogen (BUN), high sensitive C reactive protein (hs-CRP) and tumor necrosis factor (TNF-a), interleukin 6 (IL-6) were significantly lower, the difference is statistically significant (control group:t =6.944, t =2.211, t =2.623, t =5.431, t =6.181; study group:t =7.032, t =8.683, t =4.519, t =4.372, t =7.162, P <0.05), while serum SCr without significant change , the difference was not statistically significant ( t =0.533, t =0.546, P >0.05).Compared with the control treatment group , 24h UTP in the study group, serum BUN, hs-CRP, TNF-a, IL-6 decreased significantly , the difference was statistically significant ( t =2.661, t =5.461, t =4.382, t =7.222, t =5.352, P <0.05), the differences in the levels of Scr no statistical significance ( t =0.192, P >0.05). Conclusion Yiqiyangyinhuoxuetongluo decoction can significantly reduced DN patients'urinary protein excretion ,protect renal function, regulation of inflammatory mediators and significantly improve the clinical efficacy .
Keywords：Yiqiyangyinhuoxuetongluo decoctionDiabetic nephropathyRenal functionInflammatory factors
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 923-925,930 )