Effect of glucocorticoid pulse therapy in the treatment of interstitial lung disease combined with severe pneumonia
YIN Chengwei
LI Shufang
ZHANG Tao
QIU Zhengwei
Abstract：Objective To explore the effects of glucocorticoid pulse therapy in the treatment of interstitial lung dis-ease ( ILD) combined with severe pneumonia .Methods Sixty-eight cases of ILD combined with severe pneumonia were ran-domly divided into two groups .Conventional treatment including anti-infection and anti-fibrosis.Control group ( n =34) was not given glucocorticoid , treatment group ( n =34) was given methylprednisolone 40mg/d intravenous infusion for once every 8 hours, then decreased to 40mg/d intravenous infusion for once every 12 hours after the improvement of blood gas and signs , and minus 20 mg methylprednisolone every three days .The total treatment course was 2 weeks.The disappeared time of clini-cal symptoms and signs , CRP score, changes of arterial blood gas , blood lactic acid and complications between two groups were compared.Results Compared with control group , disappeared time of fever , gasping, lung rale and cough in treatment group were significantly shortened ( t =12.67, t =6.02, t =8.10, t =2.21, all P <0.05).After treatment, the lung ca-pacity, dispersion, FVC, FEV, lung imaging, dyspnea in both groups have improved significantly , and lung capacity, disper-sion, FEV, lung imaging, dyspnea in treatment group improved more remarkably than those of control group ( t =6.54, t =6.06, t =2.54, t =4.07, t =3.94,all P <0.05).After treatment, the blood gas indicators and blood lactic acid in both groups were significantly improved than those before treatment , and PaO2 , SaO2 and blood lactic acid in treatment group were improved more remarkably than those in control group ( t =4.87, t =2.10, t =2.84, P <0.05).There was no significant difference on complications between treatment group and control group( 17.6%vs.11.8%,χ2 =0.47, P =0.494).Conclu-sion Glucocorticoids pulse therapy can quickly reduce the inflammatory reaction for ILD combined with severe pneumonia , promote the improvement of clinical symptom and stable condition , and does not significantly increased complications .
Keywords：Severe pneumoniaInterstitial lung diseaseGlucocorticoidPulse therapy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 919-922 )