The changes of Galectin 3 in dilated cardiomyopathy and its relationship with the biomarker of collagenⅠmetabolism

TONG Min; DONG Jiamin; LIU Jing; ZHANG Qiang; CAI Wei; LV Ke

doi:10.3969/j.issn.1671-6450.2016.09.008

Abstract：Objective To identify the associates of Galectin 3 in dilated cardiomyopathy(DCM) patients ,and clarify the relationship with PIP(carboxyl terminal peptide of procollagen type I ) and CITP(carboxyl terminal telopeptide of collagen type I), biomarkers of collagen type Ⅰmetabolism.Methods From June 2014 to December 2015, in Suzhou Municipal Hospital, Department of Cardiology, patients were dilated cardiomyopathy (NYHA class III -IV) of 31 cases as the observa-tion group were enrolled , and selected at the same period 20 cases of normal cardiac function examination as healthy control group.The concentrations of serum Galectin 3, PIP and CITP in 2 groups were analyzed and compared .Results Observation group's galectin 3 levels was significantly higher than those in healthy control group [15.85 (11.7, 22.0) ng/ml vs.12.79 (8.23, 16.36) ng/ml, P =0.038], PIP level was higher than that of the healthy control group [(65.34 ±21.60) μg/L vs. (32.78 ±14.45)μg/L, t =5.93, P =0.001], CITP level is higher than that of the healthy control group [(6.35 ±2.35)μg/L vs.(5.14 ±2.32)μg/L], but the difference was not statistically significant ( t =1.80, P =0.083).Correlation a-nalysis indicated that there was a positive correlation between PIP and Galectin 3 ( r =0.325, P =0.035), and there was no clear correlation between CITP and Galectin 3 ( r =0.087, P =0.560).Conclusion The level of Galectin 3 and PIP in pa-tients with dilated cardiomyopathy was significantly higher than that in healthy people , and there was a positive correlation be-tween them.It suggested that Galectin 3 might be involved in the process of myocardial fibrosis and remodeling of dilated car-diomyopathy by interfering with the metabolism of type I collagen .