Effects of propylthiouracil in treating pregnancy with hyperthyroidism on their thyroid function and newborns

ZHU Yongning; YIN Guocai; XIE Ning; LI Huaju; GUO Lizhu

doi:10.3969/j.issn.1671-6450.2016.08.016

Abstract：Objective To analyze and investigate the effects of propylthiouracil in treating pregnancy with hyperthy-roidism on their thyroid function and newborns.Methods One hundred and eight cases of patients with hyperthyroidism in pregnancy treated in our hospital from June 2010 to August 2015 were selected, and were divided into the observation group (54 cases) and the control group (54 cases) according to their wishes.The patients of control group were treated without anti-thyroid drugs,while the patients of observation group were treated with antithyroid drug propylthiouracil.Thyroid hormone lev-els, newborns and complications of the two groups were observed and compared.Results After appropriate treatment, the levels of TT3,TT4,FT3, FT4 of observation group were all significantly lower than those of control group[(1.9 ±0.2)nmol/L, (148.6 ±22.7)nmol/L, (6.5 ±0.8)pmol/L, (21.4 ±2.6)pmol/L vs.(3.5 ±1.4)nmol/L, (296.3 ±31.9)nmol/L, (23.7 ±1.3)pmol/L, (55.8 ±3.0) pmol/L, P <0.05]; The levels of TSH of observation group were significantly better than those of control group[(2.25 ±0.29)mU/L vs.(0.11 ±0.02)mU/L, P <0.05];The fetal weight and Apgar score of observation group were significantly better than those of control group ( P <0.05); The complications of observation group were significantly less than those of control group ( P <0.05).Conclusion In treating patients with hyperthyroidism in pregnancy, propylthiouracil can significantly improve the thyroid function of patients, improve fetal weight and get fewer com-plications, which indicates that it has an important clinical significance.