The relationship of the levels of cortisol, adiponectin,nitric oxide and prognosis in elderly patients with acute trauma
PING Hu
TANG Jin
PU Yan
LIU Bo
Abstract：Objective To investigate the levels of serum cortisol ( COR) , adiponectin ( APN) , nitric oxide ( NO) , interleukin 6 ( IL-6) , tumor necrosis factor-α( TNF-α) in elderly patients with acute trauma.Methods From 2015 January to 2015 December, 45 cases of the elderly patients with acute trauma ( including 25 cases of low risk subgroup, 20 cases of high-risk subgroups) treated in the emergency medical department of Hanzhong Central Hospital of Shanxi province were en-rolled, another 40 cases of normal physical examination in our hospital were selected as healthy control group.The levels of cortisol, APN, NO, IL-6 and TNF-αwere determined by ELISA method, the changes of 1 d, 3 d, 5 d,7d, APN, TNF-α, NO, IL-6 and in trauma group were observed.Application of acute physiology and chronic health evaluation system II ( A-PACHE II) to assess the severity of the disease, and the relationship between serum cortisol, APN, NO, IL-6, TNF-αand A-PACHE II was analyzed by using Pearson correlation analysis.Results The levels of serum cortisol, NO, IL-6 and TNF-αin trauma group were significantly higher than those in healthy control group, while APN level was lower than that in healthy con-trol group, the difference was statistically significant ( P <0.05).Compared with the preoperative, after surgery, patients'1 day, 3 days, 5 days, 7 days blood cortisol, nitric oxide ( NO) , IL-6 and TNF-αlevels were significantly decreased ( F =15.963, F =10.452, F =20.125, F =12.963, P <0.05), and APN level increased significantly ( F =17.222, P <0.05).Compared with the low risk group, the levels of serum cortisol, NO, IL-6 and TNF-αwere higher in the high risk sub-group, while the APN level was decreased ( t =15.356, t =13.287, t =9.256, t =32.088, t =-8.879, P <0.05). Pearson correlation analysis showed that serum cortisol, NO, IL-6, TNF-αand APACHE II were positively correlated ( r =0.326, r =0.302, r =0.348, r =0.310, P <0.05), while APN and APACHE II was negatively correlated ( r =-0.339, P <0.05).Conclusion Dynamic monitoring in elderly patients with acute traumatic patient's blood cortisol, APN, no and IL-6 and TNF-αlevels will help to timely and accurately make judgment and predict the prognosis of patients, which is helpful in the clinic in a timely manner to develop an appropriate treatment program.
Keywords：CortisolAdiponectinNitric oxideInterleukin 6Tumor necrosis factor-αSevere traumaPrognosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 821-824 )