Expression of Tip30 and p53 in gastric cancer and its clinical significance
CHENG Zhiyong
YANG Yanhong
LI Tao
SHI Wenzong
YANG Lili
LI Gaoyan
MEN Xiaoyan
Abstract：Objective To investigate the expression of Tip30 and p53 in gastric carcinoma and its clinical signifi-cance.Methods 60 cases of patients with gastric carcinoma were selected from expression was detected by SP immunohisto-chemistry in 60 cases of gastric cancer tissues and adjacent normal tissues of Tip30 and p53.Results the positive rate of Tip30 in 60 cases of cancer tissues was 46.67%, which was lower than that of 95.00%(57/60) ( P <0.05) in the normal tissue adjacent to the cancer.The positive rate of p53 in 60 cases of gastric cancer tissues was 48.33%(29/60) , which was higher than the adjacent normal tissues 5.00%( P <0.05).The related factors of Tip30 protein expression in gastric cancer patients including clinical stage, differentiation, lymph node metastasis, invasion degree ( P <0.05).The expression of p53 and gastric cancer invasion, clinical stage and lymph node metastasis ( r =-0.637, P <0.05).Conclusion The high ex-pression of p53 and low expression of Tip30 can be used as an important index to predict poor prognosis of the gastric cancer.
Keywords：Gastric carcinomaTip30 proteinp53 proteinPrognosisCorrelation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 813-816 )