Therapeutic effects comparison of tibolone and Kuntai capsules in menopausal syndrome and influence on E2, FSH, endometrial thickness

SHANG Youqin; CHENG Wenjing; SUN Hongwei; WANG Rong; CHE Xiaoping

doi:10.3969/j.issn.1671-6450.2016.07.017

Abstract：Objective To compare estrogen (E2), follicle stimulating hormone (FSH) and endometrial thickness effects of tibolone and Kuntai capsules on menopausal syndrome .Methods Selection of 78 cases of menopausal syndrome in the Department of Obstetrics and Gynecology , Erdos Central Hospital, Kangbashi from June 2014 to May 2015, according to the lottery method, they were randomly divided into experimental group and control group , each group of 39 cases.Test group was treated with Kuntai capsules, 4 grains /time, 3 times daily; and the control group with oral administration for tibolone tablets, 2.5 mg, once a day, a course of 3 months.Observe the 2 groups of patients with different time Kupperman score (KI) situation, compare the two groups of patients before and after treatment of 3 months levels of sex hormone and serum lip -id levels and endometrial thickness and after treatment of clinical curative effect .Results After treatment, in the test group, the total effective rate was 92.31% (36 /39), which was significantly higher than that of the control group of 71.80% (28 /39), the difference was statistically significant (χ2 =5.571, P <0.05).Before treatment, the differences in KI scores be-tween two groups of patients showed no statistical significance ( P >0.05); 1 month, 2 months and 3 months after treatment, KI scores of two groups of patients were significantly lower than before treatment (test group: F =944.47,control group: F =877.17, P <0.01), but patients in the two groups after treatment 's KI score's differences were not statistical significance (P >0.05).Conclusion The Kuntai capsules and tibolone can improve climacteric syndrome in patients with clinical symp -toms and estradiol levels, but the Kuntai capsules is more effective than tibolone .