Effect of self-made Xiexintianzefang on expression level of TGF-β1 and IL-10 in children with recurrent Aphthous ul-cer

XU Nan; GUO Jianru; LI Changqing; HUO Bingxin

doi:10.3969/j.issn.1671-6450.2016.07.014

Abstract：Objective To investigate the curative effect of Xiexintianzefang for the recurrent aphthous ulcer of chil -dren and its influence for transforming growth factor beta (TGF-β1 ) and interleukin 10 (IL-10) level in the peripheral blood. Methods 60 cases of children with recurrent aphthous ulcer were enrolled into this study , and were randomly divided into control group (30 cases) and herb group (30 cases).The control group were orally received compound vitamin B and vitamin C pills, the herb group were treated with Xiexintianzefang for 7 days; during the period, its efficacy and safety were observed and the level of TGF-β1 and IL-10 in peripheral blood were detected.Results The Chinese medicine group total effective rate was 90.0%, significantly higher than the control group 63.3% (χ2 =11.589, P <0.01).Syndrome score after treatment, the patients in the two groups were lower than those before treatment ( P <0.01), Chinese medicine group of patients with syndrome score better than those in the control group ( t =3.91, t =7.43, t =12.58, t =10.21, t =15.57, P <0.05). The two groups after treatment in children with serum TGF -β1 and IL-10 levels decreased significantly (Chinese medicine group: t =-4.55, t =6.01, P =0.01, P =0.01; control group: t =-2.67, t =4.66, P =0.01, P =0.01), and tradi-tional Chinese medicine group was significantly better than the control group , the difference is statistically significant ( t =-3.49, t =-4.92, P =0.01, P =0.01).Conclusion The curative effect of Xiexintianzefang is better for recurrent aph-thous ulcer in children, its mechanism may be related to regulating cellular immunity .