The effect of intestinal barrier function and inflammatory cytokines after laparoscopic gastrectomy
CHENG Jun
HU Xiaoli
YANG Xiao
WANG Liang
Abstract：Objective To study the effect of laparoscopic radical gastrectomy on intestinal barrier function and in -flammatory factors in patients with gastric cancer .Methods Sixty-six cases of gastric cancer patients from May 2013 to May 2014 in Department of general surgery , Qianjiang Central Hospital were enrolled .According to random number table method, they were divided into the following group , the laparoscopic gastrectomy of 33 patients as the observation group , open radical surgery of 33 patients as the control group.Surgery situation of two groups patients were observed , plasma lactate concentra-tions, D dioxide enzymes, C reactive protein levels (CRP), and inflammatory in different time were compared .Results The incision length were (6.23 ±0.87) cm, the amount of bleeding were (125.35 ±15.21) ml, the time required for the recov-ery of intestinal function were (3.02 ±0.58) d, and length of hospital stay were (8.93 ±1.79) d of the observation group, which were significantly better than the control group ’ s (14.69 ±2.02) cm, (293.24 ±18.29) ml, (4.87 ±1.01) d, (15.02 ±3.11) d, the difference were statistically significant ( t =22.097, t =40.544, t =9.125, t =9.750, P <0.05). Preoperative 1 d, 2 groups of patients’ D lactic acid, diamine oxidase, CRP levels had no obvious difference ( P >0.05). Postoperative 1 d, 5 d ,7 d, 10 d, patients’ D lactic acid, diamine oxidase, CRP levels compared with preoperative 1 d were characterized by different degrees of decline ( P <0.01).In each period, the observation group of patients ’ postoperative D lactic acid concentration was significantly lower than the control group ; the differences were statistically significant ( P <0.05).12 h after surgery, observation group’s IL-6, IL-8, TNF-αlevel significantly lower than the control group [(21.32 ± 2.02) ng/L, (17.87 ±2.43) ng/L, (124.57 ±10.32) pg/ml vs.(30.32 ±2.54) ng/L, (25.32 ±3.21) ng/L, (153.26 ± 13.25) pg/ml)] ( t =15.931, t =10.630, t =9.813, P <0.05).Conclusion Laparoscopic gastrectomy is a relatively safe and effective procedure, the intestinal barrier function and body 's stress response have little effect , which can be more beneficial to patients in a short time to recover , it is worth in clinical application.
Keywords：LaparoscopicGastrectomyInflammatory cytokinesIntestinal barrier function
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 698-701,705 )