The therapeutic effect of combination dopamine and pramipexole in patients with Parkinson's disease：the influence of blood uric acid level and life quality

MA Yu; JIN Ge; JIANG Fan; ZHAN Qunling; LI Xinggui

doi:10.3969/j.issn.1671-6450.2016.07.006

Abstract：Objective To observe the clinical curative effect of Madopar and pramipexole in patients with Parkinson 's disease and impact on quality of life and the level of blood uric acid .Methods From January 2013 to June 2015,100 cases of Parkinson's disease were enrolled, in according to a random draw method , they were divided into observation group and control group, each of 50 cases, control group patients were treated with Madopar treatment , observation group also combined use of pramipexole, 2 groups of patients were treated for 3 months, then observed changes in the level of blood uric acid and clinical curative effect; assessment of the quality of life scale 2(QOL-2)score of two groups of patients before and after treatment , and Unified Parkinson's disease rating table (UPDRS) were assessed, and recorded adverse reactions .Results After the treat-ment, the total effective rate in observation group was significantly higher than that of the control (90.0% vs.52.0%,χ2 =55.117, P <0.05); in observation group, the level of blood uric acid higher than that of the control group [ (269.35 ± 80.45)μmol /L vs.(238.64 ±69.65)μmol/L, t =2.041, P <0.05), QOL-2 score and UPDRS scores were better than controls, differences were statistically significant ( P <0.05), 2 groups of patients in the course of treatment , the adverse re-actions occurred rate difference was not statistically significant (8.0% vs.14.0%,χ2 =0.919, P >0.05).Conclusion Madopar and pramipexole treatment for Parkinson 's disease can stabilize the patient's serum uric acid level, and effectively im-prove the quality of life of patients , improve clinical curative effect with high safety .