The expression and clinical significance of soluble B7-H4 in serum and pleural effusion in lung cancer
REN Haipeng
XIAO Haifeng
GAO Jianfeng
LI Rui
CAO Zhihui
Abstract：Objective To explore the clinical significance of the level changes of B7-H4 in serum and pleural effu-sion for patients with lung cancer.Methods Sixty-five lung cancer patients with malignant pleural effusion ( lung cancer group) and 33 benign pulmonary disease patients with pleural effusion ( control group) in our hospital from January 2014 to July 2015 were rolled in this study.The levels of B7-H4 in serum and pleural effusion were detected by enzyme-linked immu-nosorbent assay( ELISA) , and the level differences of the two group were compared.The relationship between B7-H4 and clinical data of tumor patients was analysed, and the ROC analysis were used to estimate the diagnosis value of the B7-H4 for lung cancer.Results The serum and pleural effusion levels of the B7-H4 in lung cancer patients were significantly higher than those of the control group ( P <0.01) .The serum and pleural effusion levels of B7-H4 in lung cancer patients were associat-ed with TNM stages and tumor metastasis.The serum B7-H4 level in lung cancer patients was positively correlated with serum CEA ( r =0.232, P <0.01) and was not related to serum CYFRA21-1 ( r =0.350, P >0.05) through the Spearman cor-relation analysis.The level of B7-H4 in pleural effusion was positively correlated with CEA and CYFRA21-1 in pleural effu-sion ( r =0.416, P <0.01;r =0.324, P <0.05).The AUC of serum B7-H4 for diagnosis of lung cancer was 0.807,and the best threshold value was 33.86 ng/ml with a sensitivity of 72.7%and a specificity of 76.2%.and the AUC of pleural effusion B7-H4 for diagnosis of malignant pleural effusion was 0.848,and the best threshold value was 50.3 ng/ml with a sensitivity of 72.3%and a specificity of 81.8%.Conclusion The serum and pleural effusion levels of B7-H4 were increased in lung pa-tients,and associated with the stages and metastasis of the tumor.The serum B7-H4 might be an helpful diagnosis of lung cancer, and the pleural effusion B7-H4 might be a good biomarker in the differential diagnoses of malignant/benign pleural effusion.
Keywords：Lung cancerSerumPleural effusionB7-H4
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 479-482 )