The relationship of SFRP5 and body fat parameters, glucolipid metabolism,insulin resistance and inflammatory rea-ction in type 2 diabetes
LUO Li
ZHANG Li
WANG Chenfei
ZHANG Chunxue
LU Chunhui
WANG Minzhe
Abstract：Objective To investigate the relationship of secreted frizzled-related protein 5 ( SFRP5) and lipid param-eters, glucolipid metabolism, insulin resistance and inflammatory reaction in the patients with type 2 diabetes mellitus( DM) . Methods Ninety cases of patients with type 2 DM in Fifth Affiliated Hospital of Xinjiang Medical University from May 2013 to April 2015 were selected as diabetic group, and according to body mass index ( BMI) whether is 25 kg/m2 or higher, they were divided into normal body mass group (41 cases) and overweight group (49 cases).Meanwhile, 90 subjects with normal glucose tolerance test (OGTT) were collected as normal group.SFRP5, body fat parameters, glucolipid metabolism, insulin resistance and levels of inflammatory reaction markers of each group were detected and the correlations were analyzed.Results The levels of FPG, 2hPG, HbA1c , FINS, HOMA-IR, TG,IL-6 of patients in diabetic group were all significantly higher than the normal group subjects ( P <0.05);while the levels of HDL-C and SFRP5 were significantly lower than normal sub-jects ( P <0.05).The levels of FINS, HOMA-IR, TG, IL-6 of the normal weight group were lower than the overweight pa-tients ( P <0.05),whereas HDL-C and SFRP5 levels were significantly higher than overweight patients ( P <0.05); The results show that SFRP5 level has a negative correlation with FINS, HOMA-IR, TG and IL-6 ( r =-0.392, -0.517,-0.350,-0.420, P <0.05) .Conclusion SFRP5 level in the patients with type 2 diabetes mellitus was lower than normal subjects and the results show that SFRP5 level has a negative correlation with FINS, HOMA-IR, TG and IL-6.
Keywords：Fat factorSecreted frizzled-related protein 5Body fat parametersLipid metabolismInsulin resistanceIinflammatory reaction
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 468-471 )