The study of correlation between serum resistin and metabolic index in elderly diabetic patients with coronary heart disease

LIU Chuan; MA Shu; YANG Wei

doi:10.3969/j.issn.1671-6450.2016.05.007

Abstract：Objective To investigate the relationship between serum resistin level and metabolic index in elderly type 2 diabetes mellitus with coronary heart disease.Methods Select from 2011 April to October 2014, 87 cases of elderly type 2 diabetic patients in Beijing Xuanwu Hospital, Capital University of Medical Sciences were enrolled and divided into simple di-abetes group (disease group, 45 cases) and coronary heart disease group (hypertension group, 42 cases), and selected 30 cases of the same elderly health examination as control ( healthy control group) .Determination of fasting serum resistin, fast-ing plasma glucose (FPG), meal after 2 hour plasma glucose (2 hPG), fasting insulin (FINS) and lipid levels cholesterol ( TC) ,triglycerine ( TG) , high density lipoprotein cholesterol ( HDL-C) , low density lipoprotein cholesterol ( LDL-C);insu-lin homeostasis assessment index ( HOMA-IR) evaluation of insulin resistance, analyze the correlation among the indexes.Re-sults The serum resistin levels in patients with the order of simple group >disease group >healthy control group [ respec-tively (4.98 ±1.14) ng/ml, (4.02 ±0.76) ng/ml, (1.59 ±0.91) ng/ml, F =23.025, P <0.01].Correlation analysis showed that, serum resistin levels and BMI, HOMA-IR showed significant positive correlation ( r =0.578, P <0.05;r =0.792, P <0.05), and HDL C was negative correlated ( r =-0.738, P <0.05).Conclusion Elderly type 2 diabetes mellitus complicated with coronary heart disease patient blood serum resistin level significantly increased, suggesting that in di-abetes with the development process to vascular lesions, the serum resistin may play a certain role.