Effect ofα-thioctic acid combined with mecobalamin on the superoxide dismutase level and urodynamics in patients with diabetic neurogenie bladder
WANG Feng
LI Fan
WANG Jifeng
LI Wenqiang
WU Zhihui
WANG Shuangfeng
Abstract：Objective To investigate the alpha lipoic acid combined with mecobalamin on diabetic neurogenic blad-der urine flow dynamics and serum superoxide dismutase (SOD).Methods From June 2015 to June 2014, 70 cases of dia-betic neurogenic bladder were randomly divided into observation group and control group, 35 cases in each group, they were randomly divided into the observation group and the control group.In the control group,patients were treated with Mecobal-amin, observation group patients treated with alpha lipoic acid combined with mecobalamin , before and after the treatment, the patients in the two groups’ urine flow dynamic indexes, bladder residual urine and SOD level were compared .Rseults (1) Compared with that before treatment, 2 groups of patients’ maximal urinary flow rate (MFR), maximum urinary flow rate when the detrusor pressure ( PQmax ) , urinary bladder maximum piezometric capacity VMBC were significantly improved (P <0.05), and observation group was better than the control group ( P <0.05).(2) Compared with that before treat-ment, after treatment, the patients in the two groups’ bladder compliance (BC) increased significantly ( P <0.05), obser-vation group’ s functional urethral length ( LSF) , maximum urethral pressure ( PMU) and the control group’ s PMU decreased significantly ( P <0.05), and the observation group’ s BC,LSF, PMU was better than that of the control group ( P <0.05).(3) The residual urine volume in the 2 groups of patients after treatment were significantly lower than before treat -ment,the difference was statistically significant ( P <0.05) , and the observation group decreased more significantly ( P <0.05).(4) Compared with that before treatment, after treatment, the control group’s level of SOD had no significant change ( P >0.05), observation group patients’ serum SOD level significantly increased ( P <0.05), and the observation group was significantly higher than that of the control group, the difference was statistically significant ( P <0.05).Conclusion Alpha lipoic acid combined with mecobalamin in treatment of diabetic neurogenic bladder can significantly improve urine flow dynamic indexes and the bladder residual urine volume and improving the ability of antioxidative stress , which is worthy of clinical popularization and application.
Keywords：Alpha thioctic acidMecobalaminNeurogenie bladderdiabeticSuperoxide dismutaseUrodynamics
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 456-459 )