Correlation analysis of the level of cerebrospinal fluid histamine and EDSS score in patients with multiple sclerosis

GENG Jia; ZHU Xiaofei; MA Shu; LIU Shixiang; LIU Guoyi

doi:10.3969/j.issn.1671-6450.2016.05.001

Abstract：Objective To analyze the correlation between the level of cerebrospinal fluid ( CSF) histamine and the degree of clinical neurological dysfunction in patients with multiple sclerosis (MS).Methods From October 2014 to June 2015, 46 MS patients who were admitted to Department of neurology, Kunming Medical University First Affiliated Hospital were enrolled as observation group, including the relapsing remitting MS (RRMS) subgroup of patients (29 cases) and sec-ondary progressive MS ( SPMS sub group) of 17 patients.40 cases of healthy volunteers were enrolled as healthy control group, by enzyme linked immunosorbent assay ( ELISA) , CSF histamine levels of the two groups were detected and compared and analysis histamine levels and clinical extended disability scale score ( EDSS) correlation.Results The histamine levels in the observation group were significantly higher than those in the healthy control group [(36.4 ±8.7) pg/ml vs.(8.9 ±3.7) pg /ml, t=2 .86, P <0.01].EDSS score was higher than that of healthy control group[ (3.8 ±1.1) points vs.(0.3 ±0.1) points, t =3.74, P <0.01].RRMS subgroup histamine levels below the SPMS subgroups of patients [(32.2 ±8.6) pg /ml vs.( 40.6 ±5.1) pg /ml, t =2.09, P<0 .05];EDSS score was significantly lower than that of SPMS subgroup [(2.5 ± 1.2)points vs.(4.9 ±1.4)points, t =2.82, P <0.01].The levels of histamine in MS patients were positively correlated with EDSS score ( r =0.66, P <0.01).Co nclusion Cerebrospinal fluid histamine can be used as a laboratory index for evaluating the degree of disability in MS,and histamine and its receptors may be potential targets for the treatment of MS .