The relationship of the expression of peripheral-blood sFIt-1,β-hCG, PAPP-A, AFP and early onset preeclampsia
DU Juan
ZHU Yilin
GAO Xuemei
HE Yi
Abstract：Objective To investigate the relationship of the expression of peripheral-blood vascular endothelial growth factor receptor-1 ( sFIt-1 ) , human chorionic gonadotropin (β-hCG ) , first trimester pregnancy associated plasma protein A ( PAPP-A) , alpha-fetoprotein ( AFP) and early onset preeclampsia ( PE) .Methods 84 cases of PE (48 cases of early on-set, late-onset 36 cases) were selected in our hospital from October 2014 to October 2015.Meanwhile,80 cases of normal pregnancy women were selected as the control group.The levels of peripheral-blood sFIt-1,β-hCG, PAPP-A, AFP of all pa-tients were measured by ELISA.The diagnostic value ofβ-hCG, PAPP-A, AFP of early-onset preeclampsia were analyzed by application-specific subjects curve (ROC).Results The levels of peripheral-blood sFIt-1,β-hCG, PAPP-A, AFP in the PE patients of early-onset group were all higher than the control group ( t =9.236, t =10.422, t =11.986, t =14.785, P <0.05), while the levels of sFIt-1, PAPP-A, AFP of early-onset were higher than late-onset( t =9.236, t =7.458, t =10.252, P <0.05), and there was no significant difference between the levels of peripheral-blood sFIt-1, PAPP-A, AFP of late-onset groupand the control group( t =0.785, t =0.902, t =0.525, P >0.05).The levels of peripheral-blood sFIt-1,β-hCG, PAPP-A, AFP of early-onset severe PE were higher than mild group ( t =6.271, t =31.680, t =3.449, t =5.045, P <0.05), and there was no significant difference between the levels of peripheral-blood sFIt-1, PAPP-A, AFP of delayed severe patients and the mild group ( t =0.598, t =0.230, t =0.437, P <0.05), andβ-hCG was statistically sig-nificant( t =6.043, P <0.05).ROC analysis shows that the sensitivity and specificity of sFIt-1+β-hCG+PAPP-A+AFP joint diagnosis of early-onset PE were higher than single index detection.Conclusion There is a close relationship between periph-eral blood sFIt-1,β-hCG, PAPP-A, AFP levels and early-onset PE, and different pathogenesis may exist between early-onset and late-onset PE.It can enhance the diagnostic sensitivity of early-onset preeclampsia with combination of multiple indexes.
Keywords：Soluble vascular endothelial growth factor receptor 1Human chorionic gonadotropinEarly pregnancy associated protein AAlpha fetoproteinEarly onset preeclampsia
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 394-397 )