Effect of lanthanum carbonate combined calcium acetate on calcium and phosphorus metabolism in patients with mai-ntenance hemodialysis
WANG Jiali
YANG Han
ZHANG Lin
LIAO Dan
ZHANG Fenglian
Abstract：Objective To investigate the effect of lanthanum carbonate combined calcium acetate in maintaining he-modialysis patients.Methods Seventy-eighy cases of maintenance hemodialysis patients in Mianyang Central Hospital from December 2014 to January 2009 were randomly divided into 3 groups:lanthanum carbonate group (16 cases), calcium acetate group (37 cases) and lanthanum carbonate group ( combined group 25 cases) .Treatment of 12 weeks, compared the 3 groups of patients'calcium and phosphorus metabolism.Results ( 1 ) Calcium and phosphorus metabolism: Compared with before treatment, serum calcium levels after 12 weeks in the three groups showed no significant changes, the difference was not statis-tically significant ( P >0.05), serum phosphorus, serum calcium and phosphorus product parathyroid hormone (iPTH) were significantly lower, the difference was statistically significant (lanthanum carbonate group:t =5.88,2.22,6.20,calcium ace-tate group:t =5.11,3.28,6.02, combined group:t =10.08,6.90,9.33, P <0.05), which reduced most obvious in com-bination group ( F =6.88, F =5.86, F =3.54, P <0.05).(2)Renal function and Hb levels:compared with before treat-ment, after 12 weeks of treatment, these indices were significantly decreased in 3 groups, the difference was statistically sig-nificant (lanthanum carbonate group:t =3.04,4.02,calcium acetate group:t =4.85,4.04,combined group:t =4.93, 3.37, P <0.05), while Alb and Hb levels had no significant differences ( P >0.05);among the three groups, before and after treatment, the indicators showed no significant differences ( P >0.05).(3)Ultrasound:3 groups of patients before and after treatment of carotid intimal thickening and plaque formation ratio's difference did not show statistically significant ( P >0.05).Conclusion Lanthanum carbonate combined with calcium acetate can be used in the treatment of chronic kidney dis-ease hemodialysis patients with high phosphorus, it can effectively reduce the level of serum phosphorus and PTH.
Keywords：Lanthanum carbonateCalcium acetateMaintenance hemodialysisCalcium and phosphorus metabolism
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 276-279 )