The influence of Sitagliptin on serum levels of pro inflammatory and anti inflammatory cytokines in patients with au-toimmune diabetes
ZHOU Rendong
YANG Angui
RU Hongming
GENG Jinping
Abstract：Objective To observe the effect of sitagliptin on the level of inflammatory cytokines and anti inflammatory cytokines in patients with autoimmune diabetes mellitus ( LADA) .Methods Selected 36 cases of LADA patients from Janu-ary 2012 to December 2014 treated at Hubei Zhongxiang City People 's Hospital, they were randomly divided to sitagliptin (n =18) group and insulin group ( n =18), and 20 cases non-diabetic healthy volunteers with gender, age-matched as healthy control group.After treatment of 3 months, inflammatory factor (INF-γand TNF-α, IL-1βand IL-6) and anti-inflam-matory cytokines (IL-10, TGF-β, IL-4) index were compared.Results Before treatment, LADA serum proinflammatory cy-tokines were significantly higher than control group ( P <0.05).After treatment, sitagliptin group patient's TNF-α, IL-1βand IL-2 level decreased most obviously ( P <0.05), and insulin group only IL-6 levels decreased with statistical significance ( P <0.05), and sitagliptin group's TNF-α, IL-1βdeclined obviously than insulin group ( P <0.05), before treatmen, LADA patient's anti-inflammatory cytokines were lower than the healthy control group ( P <0.05) .Sitagliptin group and in-sulin group's IL-10 and TGF-βlevels increased after treatment, and the difference were statistically significant ( P <0.05), but difference between the 2 groups showed no statistical significance ( P >0.05).Sitagliptin and pro inflammatory factor of△TNF-αand△IL-6 had a significantly negative correlation ( r =-0.718, r =-0.762, P <0.05), and significantly posi-tive correlated with anti-inflammatory factor of△IL-10 and△TGF-β( r =0.677, r =0.712, P <0.05) .Conclusion Sita-gliptin can effectively regulate inflammation and anti-inflammatory system balance in patients with LADA, improve chronic in-flammatory factors'body damage.
Keywords：SitagliptinAutoimmune diabetes mellitusInfcammatory cytokinesAnti-inflammatory cytokines
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 264-267 )