The impact of brain function and local glucose metabolism of subthalamic nucleus stimulation in Parkinson's disease patients
LIU Danrong
HU Wei
YOU Zhijun
DENG Chao
Abstract：Objective To investigate the effect of subthalamic nucleus stimulation ( STN-DBS) in Parkinson disease ( PD) brain function in patients with local glucose metabolism abnormal.Methods From June 2011 to June 2014, 60 cases of PD patients in Shiyan people's Hospital, Hubei Medical College were enrolled in this study, they were randomly divided into observation group and control group with 30 cases in each group.Control group was given oral levodopa daily, the observation group based on the treatment in the control group, also added the uplink STN-DBS treatment, before treatment and after treat-ment for 3 months, using Unified Parkinson's Disease Rating Scale ( UPDRS) to assess motor function of patients in two groups respectively, using the Montreal Cognitive Assessment Scale ( MoCA) and mini mental state table ( MMSE) to evaluate neural function and patients were underwent the resting F-deoxyglucose FDG/PET examination.Results Compared with before treat-ment, after treatment, the two groups of patients'UPDRS total score decreased significantly ( P <0.05), the observation group's score were lower than the control group ( P <0.05);and the MMSE, MOCA score were only improved in the obser-vation group after treatment ( P <0.05), and significantly higher than control group ( P <0.05).By FDG /PET, the ob-servation group after treatment's frontal lobe, temporal lobe, parietal lobe, occipital lobe, caudate nucleus, hammer-shaped nucleus, cerebellum, thalamus, cingulate cortex and other parts of the semi-quantitative metabolic radiation count was signifi-cantly higher than before treatment ( P <0.05), after treatment, each brain region metabolic semi-quantitative radiation count differences in the control group was not shown statistically significant ( P >0.05), and significantly higher in the obser-vation group than the control group ( P <0.05).After treatment, observation group's daily oral dose of levodopa significantly less than before treatment and control group ( P <0.05) , dyskinesia and motor fluctuations were significantly lower than inthe control group (3 y.33%vs.26.67%, 0 vs.20.00%, P <0.05).Conclusion The STN-DBS can effectively improve the PD patient's brain glucose metabolism and brain function, promote the coordination of limb, improve limb movement func-tion, improve the quality of life of patients.
Keywords：Parkinson's diseaseSubthalamic stimulationBrain functionLocal glucose metabolismMotor function
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 249-252 )