The analysis on correlation between serum antioxidant and cognitive impairment in patients with Alzheimer's disease
QIU Haipeng
ZHANG Xiaoxuan
ZHU Yunbo
GAO Yanjun.
Abstract：Objective To investigate the correlation between serum antioxidant and cognitive impairment in patients with Alzheimer's disease( AD) .Methods Analyzing clinical data of 41 cases Alzheimer's patients for treatment in the Cheng-de Medical College Affiliated Hospital from January 2014 to June 2014, they were selected as observation group, and 44 cases elderly health people for check-up were selected as control group.MMSE total scores, blood lipid, oxidation index and super-oxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the amount of 8-iso-prostaglandin (8-iso-PGF2α) in urine were compared between the two groups.Results MMSE total scores in observation group patients was obviously lower than the control group, the difference is statistically significant ( t =8.813, P <0.01).The scores of naming ability, language abili-ty, delayed recall, directional ability, visual space and execution, attention and calculation ability in control group were high-er than the observation group, difference have statistically significant ( P <0.05);Compared to serum TG, TC, HDL-C and LDL-C level in two groups patients, difference have no statistically significant ( P >0.05 ) .The MDA amd urine 8-iso-PGF2αlevel in observation group were significantly higher than the control group, the difference was statistically significant (t =12.25, t =46.18, P <0.01);serum SOD ( t =3.973, P <0.01), GSH-Px ( t =5.966, P <0.01) levels in the observation group of patients were significantly lower than the control group, the difference have statistically significant ( P <0.05).By Pearson correlation analysis, serum SOD in observation group appears positive correlation with MMSE score ( r =0.527, P <0.01), GSH-Px appears positive correlation with MMSE score ( r =0.471, P =0.002), at the same time, the 8-iso-PGF2αin urine showed significant negative correlation with MMSE score ( r =-0.456, P =0.003).Conclusion The decrease of SOD,GSH-Px and rising of MDA,8-iso-PGF2αlevel play an important role in the onset of cognitive impairment of AD patients, they can be used for clinical diagnosis and treatment.
Keywords：Alzheimer diseaseAntioxidantCognitive impairment
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 245-248 )