The impacts of remtoe ischemia post-conditioning on serum pro-inflammatory factors and anti-inflammatory factors and its clinical signfi cance in patients with acute cerebral infa rction
Abstract：Objective To evaluate the impacts of remote ischemia post-conditioning( RIPC) on serum pro-inflamma-tory factors and anti-inflammatory factors and its clinical significance in patients with acute cerebral infarction.Methods A total of 100 consecutive patients with acute cerebral infarction in Department of Neurology of Wuhan Sixth Hospital Affiliated to Jianghan University from January 2012 to June 2015 were included in this study and were randomly divided into RIPC group and control group, 50 cases for each group.The control group was given conventional treatment, and the observation group re-ceived additional RIPC treatment.The changes of serum pro-inflammatory factors ( INFγ, TNF-α, IL-18 and IL-8) and anti-inflammatory factors (IL-13,TGFβand IL-4) were compared before treatment and 2 weeks after treatment.Results There were no significant differences in pro-inflammatory factors and anti-inflammatory factors before and after treatment in the con -trol group (P >0.05).The levels of serum TNF -α[(102.7 ±22.8) pg/ml vs.(61.3 ±12.1) pg/ml, t =2.335, P =0.013] and IL-18[(37.7 ±5.4) pg/ml vs.(14.3 ±3.7) pg/ml, t =2.247, P =0.016] were significantly reduced after treatment, while levels of serum IL-13 [(15.9 ±3.6) pg/ml vs.(52.2 ±4.1) pg/ml, t =2.300, P =0.014] were signifi-cantly increased in the observation group, and improvements was superior to that in control group,there were significant differ-ences( P <0.05).Correlation Analysis showed that RIPC was positively associated with △TNF-α( r =0.641, P <0.05),△IL-18 ( r =0.687, P <0.05) and△IL-13( r =0.732, P <0.05).Conclusion RIPC may improve the pro-in-flammatory/anti-inflammatory system in patients with acute cerebral infarction , which may be a potential treatment method of acute cerebral infarction.
Keywords：Remote ischemia post-conditioningCerebral infarctionacutePro-inflammatory factorAnti-inflammato-ry factor
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 241-244 )