Clinical study on small volume lung lavage in treatment of silicosis patients complicated with chronic obstructive pul-monary disease
WANG Li
CHANG Xiaohong
Abstract：Objective To explore clinical efficacy of conventional symptomatic treatment combined with small volume lung lavage in treatment of silicosis patients complicated with severe stable chronic obstructive pulmonary disease (COPD). Methods From 2012 August to 2015 February, selected 108 cases silicosis complicated with severe stable COPD patients in Yan'an University Affiliated Hospital as the research objects, according to the random number table method, these patients were divided into routine group and lavage group (54 cases in each group), and routine group were treated with anti-cough, anti-phlegm, anti-asthma, oxygen therapy, lavage group on the basis of control group therapy, also giving small volume lung lavage therapy, with a course of 3 months.Treatment of 1 month, then detected 2 groups of patients'serum transforming growth factor-β1 (TGF-β1 ), tumor necrosis factor -α(TNF-α) levels, compared the lung function, 6 min walking capacity and quality of life at 1 month, 3 months.Results Compared with before treatment, after treatment, the two groups'TGF-β1, TNF-αlevels decreased ( P <0.01), 1 month after the treatment, the lavage group's TGF-β1 and TNF-αwere significantly lower than those of the conventional group[TGF-β1 :(43.1 ±9.4)ng/L vs.(49.4 ±10.9) ng/L),TNF-α:(152.3 ±23.1) ng/L vs.(180.6 ±28.4) ng/L, P <0.01].There were no significant of 2 groups of patients'pulmonary function index difference between 1 and 3 months after treatment ( P >0.05).Compared with before treatment, 2 groups'6 min walking, St.George's score were improved ( P <0.05), after 1 month,3 months of therapy, lavage group's 6 min walking was significantly higher than that of the conventional group[(330.5 ±30.3)m vs.(295.3 ±27.3) m,(335.6 ±31.4)m vs.(308.8 ±29.1) m, P <0.05];after 3 months treatment, lavage group's SGRQ was significantly lower than that of and the conventional group (48.8 ±6.4 vs.53.6 ±6.8,P <0.05).Conclusion Conventional treatment combined with small volume lung lavage of silicosis complicated with severe stable COPD lung ventilation function of the patients with no obvious effect, but can reduce the levels of cytokines and significantly prolonged exercise tolerance, improve quality of life.
Keywords：SilicosisChronic obstructive pulmonary diseaseSmall volume lung lavagePulmonary functionQuality of lifeInflammatory factors
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 221-224 )