The clinical observation of Qiliqiangxin capsule on coronary heart disease and left ventricular diastolic dysfunction

WANG Xiaoning; WO Jinshan; GUO Jie

doi:10.3969/j.issn.1671-6450.2016.02.020

Abstract：Objective To observe the effect of Qiliqiangxin capsule in the treatment of coronary heart disease with di-astolic dysfunction.Methods Sixty-two cases of coronary heart disease combined with left ventricular diastolic dysfunction in department of Cardiology, Qiingdao University Medical College Affiliated Hospital from April 2014 to February 2015 were en-rolled.By using the method of random number table, 31 cases were divided into observation group and 31 cases in control group.The control group was given conventional treatment, the observation group based on the conventional treatment also added with Qiliqiangxin capsule, the course of treatment was 6 months.Before and after treatment, left atrial diameter ( LAD) , left ventricular diastolic end diastolic diameter ( LVEDD) , mitral diastolic early flow and mitral annulus velocity ratio (E/E'), left ventricular ejection ejection fraction (LVEF) were measured with ultrasound; simultaneous determination the level of plasma N-terminal pro brain natriuretic peptide precursor ( NT-proBNP) and did the comparative analysis.Results The total effective rate of observation group was significantly higher than that in the control group, the difference was statisti-cally significant (74.2% vs.51.6%, P <0.05).Compared with before treatment, after 6 months of treatment, LAD, LVEDD, NT-proBNP, E/E'were decreased in both of the two groups, LVEF value increased ( P <0.01), and the observa-tion group improved significantly compared with the control group, the difference was statistically significant ( P <0.05). Conclusion The heart function of conventional medicine combined with Qiliqiangxin capsule could significantly improve cor-onary heart disease patients with left ventricular diastolic heart dysfunction.