The levels of MIF, TLR4, TNF-αin patients with diabetic nephropathy and its clinical significance
WEI Zhengnan
LI Tao
ZHANG Qinghong
CHEN Xinhe
WU Dong
YANG Hongrong
Abstract：Objective To observe the changes and clinical significance of macrophage migration inhibitory factor ( MIF) , Toll like receptor 4 ( TLR4 ) and tumor necrosis factor-α( TNF-α) levels in patients with diabetic nephropathy. Methods 77 cases of diabetic nephropathy were selected from the Department of internal medicine, Shiyan Taihe Hospital, Hubei Province from May 2012 to April 2015.According to the urine albumin and creatinine ratio (urinary A/C), they were divided into 2 groups, urinary A/C less than or equal to 300 mg/g as group A with 42 cases, urinary A/C>300 mg/g as group B (35 cases);and chose 38 cases health examination at the same time as control group (group C).The clinical and bi-ochemical data of the 3 groups were compared with the levels of MIF, TLR4 and TNF-α, and the relationship between MIF, TLR4, TNF-αand clinical indexes of diabetic nephropathy were analyzed.Results Group A patient’ s body mass index (BMI), systolic blood pressure (SBP), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) were (26.78 ±3.46) kg/m2 , (137.43 ±10.11) mmHg, (8.81 ±0.87)%, (8.85 ±1.87) mmol/L, respectively,and group B were (27.15 ± 3.53) kg/m2 , (140.24 ±11.25) mmHg, (9.02 ±0.94)%, (8.94 ±1.91) mmol/L, which significantly higher than the group C’ s (23.43 ±3.01) kg/m2 , (122.04 ±9.55) mmHg, (5.24 ±0.32)%, (5.18 ±0.53) mmol/L, while high den-sity lipoprotein protein cholesterol (HDL-C) were lower than group C, the difference were statistically significant ( P <0.01);group B patients’ diastolic blood pressure ( DBP) , triglyceride ( TG) , total cholesterol ( TC) , creatinine ( SCr) , blood urea nitrogen (BUN) levels were (81 `.43 ±10.22) mmHg, (3.53 ±0.98) mmol/L, (5.83 ±0.99) mmol/L, (122.45 ± 15.32) μmol/L, (7.88 ±2.01) mmol/L, which were higher than group A ( P <0.01).Group A’s MIF, TLR4, TNF-αwere (143.21 ±12.32) ng/ml, (5.72 ±0.87) pg/ml, (26.98 ±5.33) pg/ml respectively, group B were (147.44 ± 13.45) ng/ml, (6.14 ±0.92) pg/ml, (28.14 ±6.21) pg/ml respectively, which were significantly higher than group C’s (113.53 ±10.43) pg/ml, (1.97 ±0.51) pg/ml, (18.45 ±4.35) pg/ml, the difference were statistically significance ( P <0.01) .MIF and duration of diabetes patients with kidney disease, HbAlc , FPG, TG were positively correlated ( r =0.435, r =0.459, r =0.521, r =0.254, P <0.05, P <0.01), and showed negative correlation with HDL-C ( r =-0.231, P <0.05);TLR4 positive correlated with diabetic nephropathy patients’ SCr, CPR, urine protein A/C ( r =0.873, r =0.901, r =0.957, r =0.676, P <0.01);serum TNF-αand course of patients with diabetic nephropathy and u-rine A/C was positively correlated ( r =0.197, r =0.254, P <0.05, P <0.01).Conclusion The levels of the MIF, TLR4, TNF-αin diabetic nephropathy patients with high expression, and correlated with diabetic nephropathy disease course.
Keywords：Macrophage migration inhibitory factorDiabetes mellitusKidney disease
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 165-168 )