The preventive effect of alprostadil lipo preparation on contrast induced nephropathy in patients with PCI

WU Ying; HE Yun; HUANG Wenhan; SHEN Zhaonan; SU Yong

doi:10.3969/j.issn.1671-6450.2016.02.012

Abstract：Objective To investigate the preventive effect of lipo PGE1 in coronary heart disease ( CHD) percutane-ous coronary intervention (PCI) for the treatment of patients with contrast media induced nephropathy (CIN).Methods From July 2012 to July 2015, 245 cases of patients with coronary heart disease in the Department of internal medicine Fifth People's Hospital of Chongqing City were enrolled, according to the random number table method, they were divided into the observation group of 123 cases and control group of 122 cases.The control group 1 h before intervention, given 3 ml· kg-1 · h-1 intravenous infusion of 0.9%sodium chloride injection, observation group give alprostadil lipo 10 μg+physiological sa-line 100 ml intravenously.Comparative analysis of two groups preoperative and postoperative 24 h, 48 h, serum creatinine ( SCr) , potassium ( K+) , blood urea nitrogen ( BUN) and urine pH value, glomerular filtration rate ( GFR) , urinary trans-ferrin ( TRF) , gelatinase lipid lipocalin ( NGAL) differences.The incidence rate of CIN and second grade event in the 2 groups were observed.Results Compared with those before operation, after operation, 2 group’ s SCr,K+,BUN,TRF, NGAL levels were increased, GFR were decreased, and in the observation group after 24 h and 48 h, SCr, K+,BUN,TRF, NGAL levels was significantly lower than those of control group ( P <0.01), and estimated GFR levels higher than that in the control group ( P <0.05).The incidence rate of CIN and second grade event incidence in the observation group were lower than those in the control group (2.44%vs.11.48%,0.81%vs.5.74%, P <0.05).Conclusion For coronary interven-tional preoperative patients using lipo prostaglandin E1 can reduce CIN incidence and effectively protect renal function.