Clinical effects and changes in CRP, BNP of patients with unstable angina in treatment with metoprolol and simvas-tatin
LI Junpeng
GAO Aihong
LIU Jilun
HE Yajun
Abstract：Objective To discuss the clinical efficacy of metoprolol combined with simvastatin on CRP and BNP lev-els in the treatment of elderly patients with unstable angina pectoris (UAP).Methods From April 2014 to May 2015, 118 cases of UAP patients in Shanxi Nuclear Industry No.215 Hospital were selected as the research object, and according to the random number table method, they were divided into observation group with 59 cases and control group with 59 cases.Treat-ment of two groups of patients after admission were given conventional oxygen, ECG monitoring, aspirin, low molecular hepa-rin sodium gel, nitrate isosorbide ester;the control group based on the conventional treatment, also combined application of metoprolol, initial dose each 12.5 mg orally, twice daily, until 25 mg, 2 times daily; observation group besides the control group treatment, also received simvastatin tablets with 20 mg /time, 1 time /d, bedtime meal service.The course of treat-ment in 2 groups was 3 months.The clinical efficacy of the 2 groups, myocardial enzyme spectrum, blood lipids, CRP, BNP levels, adverse events and cardiovascular events were observed before and after the treatment.Results After treatment, the observation groups’ total effective rate was significantly higher than that of control group (98.3% vs.84.7%,χ2 =6.993, P <0.05);2 group patients’ LDH, CK-MB, blood lipid, CRP and BNP were significantly improved compared with those before treatment (P <0.05);in the observation group, the degree of improvement were better than those of the control group ( P <0.05);observation groups’ angina attack frequency was significantly lower than that of control group ( P <0.05), and alanine aminotransferase increased, acute myocardial infarction and sudden cardiac death did not show significant differ-ence ( P >0.05).Conclusion Metoprolol combined with simvastatin in the treatment of elderly patients with unstable angi-na pectoris is effective and safe, it can significantly reduce the levels of CRP and BNP, it is worthy of clinical promotion.
Keywords：MetoprololUnstable anginaHypersensitivity C reactive proteinBrain natriuretic peptide
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 139-142 )