Therapeutic effect of idebenone combined with nimodipine in the treatment of vascular dementia after cerebral in-farction
FU Xiaoxue
XU Bo
WANG Xiaopin
YIN Liping
Abstract：Objective To observe the clinical efficacy and safety of idebenone combined with nimodipine in the treat-ment of vascular cognitive impairment ( VCI) after cerebral infarction.Methods From January 2013 to December 2014, 109 cases of patients with VD in Hainan Province Frontier Corps Hospital were enrolled, according to random number table meth-od, they were divided into combined group (55 cases) and control group (54 cases), two groups were given routine symptom-atic treatment, the control group with oral administration of nimodipine 30 mg, 3 times a day, for 3 consecutive months;com-bined group on the basis of treatment in the control group, also added idebenone 30 mg, 3 times a day.The course of treat-ment was 3 months.After treatment, the clinical efficacy of the 2 groups were observed, and the mini mental state examination scale ( MMSE) score and the change of the daily living activity ability score ( Barthel index) were recorded.Results Three months after taking medicine, the total efficiency of the combination group was higher (94.5% vs.81.5%), the difference was statistically significant (χ2 =4.427, P =0.035).Compared with before treatment, after treatment, the two groups of pa-tients with MMSE scores Barthel Index scores were gradually increased ( P <0.01).Combined group’s two months and three months’MMSE score were significantly higher than control group[(21.7 ±3.6) points vs.(20.2 ±3.2) points,(23.8 ± 4.2) points vs.(21.5 ±3.7) points, t =2.303, t =3.039, P <0.05],after 3 months of treatment, Barthel index score was significantly higher[(58.1 ±7.5) points vs.(54.6 ±6.3) points, t =2.646, P =0.009].During treatment, the two groups’ gastrointestinal discomfort, hypotension, facial flushing, rash incidence of adverse reactions’ differences were not sta-tistically significant ( P >0.05).Conclusion Idebenone and nimodipine other than single use of nimodipine can effectively improve the patient’ s life and cognition ability and has a higher tolerance and clinical safety.
Keywords：Vascular cognitive impairmentIdebenoneNimodipineMini mental state examination scoreActivities of daily livingAdverse reactions
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 119-122 )