Diagnostic value of combination with procalcitonin, hypersensitive C reactive protein and white blood cell count on infection type and prognosis of sepsis patients

YANG Yousheng; QU Xiangchun; HU Song

doi:10.3969/j.issn.1671-6450.2015.12.017

Abstract：Objective To investigate the procalcitonin ( PCT) , hypersensitive C reactive protein ( hs-CRP) and WBC combination in detection of sepsis in patients with different type and severity of infection .Methods From July 2013 to Januar-y 2015 , 72 cases of sepsis patients were selected as the research object , enrolled as sepsis group , retrospective analyzed the clinical data, according to the blood culture results, they were divided into G +bacteria subgroups and G -bacteria subgroup, according to prognosis , they were divided into survival subgroup and death subgroup , and selected the same period 54 cases of healthy persons as healthy control group , to analyze and compare the levels of serum PCT , hs-CRP and WBC levels .Results In patients with sepsis , serum PCT, hs-CRP and WBC levels were much higher than those in healthy control group , the differ-ence were statistical significance ( t =37.832, t =31.303, t =9.836, P <0.01).G+bacteria subgroup patients'serum PCT, hs-CRP level were much higher than that of the G -bacteria subgroup , the difference were statistical significance ( t =18.438, t =2.393, P <0.01 or<0.05), and G+bacteria subgroup and G -subgroup's WBC count had no statistical signifi-cance differences ( t =1.910, P >0.05).Sepsis survival subgroup's serum PCT, hs-CRP and WBC were presented with time dependent decrease after treatment , and death subgroup has no time effect , and survival subgroup's 3 indexes were much more lower than death subgroup in each time point , the difference between the two groups were statistical significance ( P <0.01).Conclusion The index of serum PCT in distinguish between G +and G-bacterial infection type for septic patients have a better clinical value .PCT, hs-CRP and WBC combined examination can help for evaluating the severity of sepsis and guide the early treatment .