Clinical study of high intensity focused ultrasound combined with IMRT treatment of advanced hepatocellular carci-noma
ZHOU Li
DU Tianxing
ZHU Xiaopeng
Abstract：Objective To investigate the clinical efficacy and safety of high intensity focused ultrasound ( HIFU) combined with intensity modulated radiation therapy in the treatment of advanced primary liver cancer .Methods From 2011 May to 2013 December , 60 patients with primary liver cancer were randomly divided into study group and control group , 30 cases in each group .The study group was treated with HIFU combined with intensity modulated radiotherapy .The short-term efficacy, pain score were compared, and detected the liver function, tumor markers (AFP, CEA), T cell subsets and NK cell level, and observed the adverse reactions of the 2 groups.Results The total effective rate of the study group was 80.0%, sig-nificantly higher than the 53.3%of control group ( P <0.05);along with increasing of the radiation dose , 2 groups’ pain scores were reduced than before treatment gradually ( P <0.05) and the degree of pain relief of the study group were more significantly than the control group , the difference was statistically significant ( P <0.05); compared the before and after treatment, total bilirubin, alanine aminotransferase , aspartate aminotransferase in the study group and the control group did not show significant differences , CEA, AFP were improved in both the two groups ( P <0.05), and the AFP in study group improved more significantly than the control group ( P <0.05 ); 4 weeks after therapy , the study group ’ s CD3+, CD4+, CD4+/CD8+,NK cells significantly improved than before the treatment and control groups ’ after 4 weeks of treatment ( P <0.05);2 group after treatment, adverse reactions mainly were leukopenia , hemoglobin, thrombocytopenia, kidney gut reac-tion, renal dysfunction,but the two groups showed no significant difference of these adverse reactions ( P >0.05).Conclusion HIFU combined with intensity modulated radiation therapy can improve the treatment effect of primary liver cancer , relieve pain,improve the quality of life ,improve the patient's immunity,and do not increase the incidence of radiation-induced liver disease.The HIFU combined with intensity modulated radiation therapy is a safe and effective method for treatment of patients with advanced liver cancer .
Keywords：Hepatocellular cancerHigh intensity focused ultrasoundIntensity modulated radiation therapy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1255-1258 )