The correlation of the level of glucagon like peptide 1 to predict the poor outcome after brain injury
LIU Mingming
KUANG Hongyu
JIANG Xiaoyan
LIU Dandan
YU Jizhu
PAN Yu
Abstract：Objective To investigate the hyperglycemia of glucagon like peptide 1 (GLP-1) level in brain trauma pa-tients with stress and its effect on prognosis .Methods Sixty-four patients with cerebral trauma were selected , including 42 patients with hyperglycemia , 22 patients with normal blood glucose .The injury severity score , the mortality rate , hospitaliza-tion time, blood glucose and GLP-1 were recorded.Follow up for 3 months, the end point was the all cause mortality .Results Hyperglycemia group's GLP-1 levels was significantly lower than that in normal blood glucose group [(1.5 ±0.9) pmol/L vs.(0.8 ±0.4)pmol/L, t =3.828, P =0.001].The mortality rate in hyperglycemia group was higher the normal blood glu-cose group(42.9%vs.13.6%,χ2 =5.592, P <0.05);GLP-1 levels and blood glucose levels were negatively correlated ( r =-0.58, P <0.01);single variable and multivariable analysis showed that injury severity score (ISS), GLP-1, blood glucose has significant prediction for endpoint ( P <0.05), GLP-1 was protective factor,injury severity score, blood glucose were risk factors.Conclusion The lower level of the GLP-1 and post-traumatic stress hyperglycemia were correlated , prognosis of the traumatic brain injuries patients with stress hyperglycemia and low GLP 1 and hyperglycemia were closely related .
Keywords：Brain injuryHyperglycemiaGlucagon like peptide 1Intensive care unit
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1249-1251,1254 )