The relat ionship between serum protein proteoglycans 1 and diabetic chronic kidn ey disease

GUO Yifei; LI Mei; WANG Xiaofen

doi:10.3969/j.issn.1671-6450.2015.12.009

Abstract：Objective To analyze the relationship between the serum protein proteoglycans 1 and diabetic chronic kidney disease .Methods From December 2012 to December 2014 , selected the patients who admitted to department of endo-crinology, they were divided into non-microalbuminuria in type 2 diabetes ( NMALB group) and microalbuminuria in type 2 diabetes (MALB group) patients, 100 cases in each group, 50 cases of normal healthy were selected as control group , fasting plasma glucose (FPG), blood urea nitrogen (BUN), serum creatinine (SCr), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol ( HDL-C) , low density lipoprotein cholesterol ( LDL-C) , very low density lipoprotein cho-lesterol (VLDL-C), glycated hemoglobin (HbA1c) and serum proteoglycans 1 were detected and compared among the three groups of patients.Results Compared with the healthy control group, NMALB and MALB group’s FPG, BUN, SCr, TG, VLDL-C were increased, HDL-C were decreased ( q =3.42, q =10.01, q =2.89, q =8.38, q =10.15, q =14.38, q =8.55, q =10.82, q =8.08, q =10.69, q =4.73, q =8.40, P <0.01 or P <0.05);MALB group’s FPG, BUN and SCr were higher in NMALB group, HDL-C were lower than NMALB group ( q =6.93, q =44.41, q =5.18, q =4.48, P <0.01 or P <0.05).NMALB group and MALB group’s serum levels of proteoglycans 1 were significantly higher than those in healthy control group ( t =4.27, t =9.25, P <0.01);MALB group’s serum level of proteoglycans 1 was significantly high-er than NMALB group ( t =10.36, P <0.01).Urine albumin and serum protein proteoglycans were positively correlated (r =0.343, P <0.01).Conclusion Serum proteoglycan 1 and microalbuminuria was positive correlated , it can be used as early detection indicator for diabetic kidney injury .