Clinical analysis of azithromycin combined Qibaiqingfei pill in treatment of children mycoplasma pneumoniae infec-tion

LI Xiaolan; LI Xiaojun; LU Jinling

doi:10.3969/j.issn.1671-6450.2015.11.022

Abstract：Objective To investigate the clinical curative effect of azithromycin combined with Qibaiqingfei pill on mycoplasma pneumonia infection in children.Methods One hundred and fifty-six children with mycoplasma pneumonia infec-tion were enrolled they were randomly assigned to three groups:Traditional Chinese medicine group, western medicine group, joint groups, and each group with 52 cases.Selected the same period 52 cases of healthy children as healthy control group, western medicine group were treated with azithromycin, Chinese medicine group received oral Qibaiqingfei pill, the joint group reveived oral azithromycin combined with Qibaiqingfei pill.Serum inflammatory factors between the 4 groups ( IL-6, IL-8, TNF-α) and immunoglobulin ( IgA, IgG, IgM) level were detected.Results After 2 weeks treatment, joint group, western medicine group and traditional Chinese medicine group’s efficiency were 98.1%(51 /52), 84.6%(44/52), 90.4%(47/52);and compared with joint group, western medicine group and Chinese medicine group were lower, the difference was statistically significant ( P <0.05).Compared with joint group, western medicine group and Chinese medicine group’ s cough disappearance time, fever disappeared time, pulmonary rales disappear time, X-ray infiltration shadow disappearance time and hospitalization time revealed statistically significant differences ( P <0.05), and no statistically significant differ-ences were found between Western medicine group and traditional Chinese medicine group ( P >0.05).Before treatment, disease group’s serum inflammatory factor levels (IL-6, IL-8, TNF-α) were significantly higher than those in healthy control group ( P <0.05);compared with before treatment, 2 weeks after treatment, 3 groups’ serum inflammatory factor levels sig-nificantly reduced ( P <0.05);and after treatment, joint group’s serum inflammatory factor levels were significantly lower than those in the Western group and traditional Chinese medicine group ( P <0.05) , western medicine group and traditional Chinese medicine group showed no statistical significance ( P >0.05).Before treatment, the disease group’s IgA level was significantly lower than that in healthy control group, IgG and IgM levels were significantly higher than those in healthy control group ( P <0.05); compared with before treatment, 2 weeks after treatment, 3 groups’ IgA level was significantly in-creased, level of IgG and IgM wer significantly reduced ( P <0.05);and the joint groups’s IgA level was significantly high-er than that of groups of Western medicine and traditional Chinese medicine, level of IgG and IgM were significantly lower than that of Western medicine group and traditional Chinese medicine group ( P <0.05) , western medicine group and traditional Chinese medicine group showed no statistical significance ( P >0.05).Conclusion It demonstrated that the Qibaiqingfei pill combined with azithromycin in treatment of children with Mycoplasma pneumonia pneumonia could reduce inflammatory cell factor level, improve immune function and the condition.