Effect of mycophenolate mofetil combined with cyclophosphamide on renal function and the level of VEGF in IgA ne-phropathy

GAO Jianmin; ZHU Qiang; ZHU Cuihua

doi:10.3969/j.issn.1671-6450.2015.11.017

Abstract：Objective To observe the effect of mycophenolate mofetil combined cyclophosphamide ( CTX) on IgA ne-phropathy and serum vascular endothelial growth factor (VEGF) in patients with diabetic nephropathy.Methods Ninty-six patients with IgA nephropathy from March 2012 to March 2015 were enrolled and divided into observation group and control group with 48 cases in each group.The control group was given to the mycophenolate mofetil continuous treatment of 12 months, the observation group on the basis of treatment in the control group, also intravenous infusion of cyclophosphamide 1000 mg/times, 1 times a month, for 6 consecutive months.After 1 years of treatment, the effect of the 2 groups were com-pared and analyzed the renal function and VEGF and other indicators of change before and after treatment.Results The total efficiency of observation group was 95.83%, which was higher than 79.17%in the control group (χ2 =6.095, P =0.013). Compared with before treatment, SCr increased, BUN, 24 hUP, VEGF, CCr were decreased after the treatment in the 2 groups, the difference was statistically significant ( P <0.05); after the treatment, BUN (4.33 ±1.24) mmol/L, SCr (86.92 ± 14.67) mol/L, 24hUP (42.86 ±5.26) mg/24h, VEGF (109.64 ±23.78) ng/ml were lower than that of the control group (7.98 ±2.53) mmol/L, (102.16 ±21.25) mol/L, (85.36 ±4.28) mg/24h,(135.25 ±26.47) ng/ml, the differences were statistically significant ( t =5.754, t =4.824, t =7.265, t =5.963, t =5.469, P <0.05);observation group's Ccr was(55.98 ±22.02) ml/min, which was higher than that of the control group(46.32 ±18.63) ml/min( t =5.963, P =0.000).The adverse reactions rate was 6.25%(3/48) in the observation group, control group was 10.42%(5/48),the difference between the two groups was not statistically significant(χ2 =0.545, P =0.462).Conclusion The clinical effect of mycophenolate mofetil combination of cyclophosphamide for IgA nephropathy patients with VEGF nephropathy can be effective.