Application of impedance cardiography in the early goal directed therapy of patients with septic shock
ZHANG Yi
HE Miao
ZHAO Juan
XIU Mingwen
LI Bingbing
Abstract：Objective To investigate the application of impedance cardiography ( ICG) in early goal directed therapy (EGDT) of patients with septic shock.Methods Selected from January 2013 to March 2015, the ICU hospitalized patients with septic shock (68 cases) as the research subject, received the EGDT under the monitoring of ICG, compared the hemody-namic parameters at 0 h and 6 h;according to the 6 h EGDT was achieving the recovery goal or not, patients were divided into sufficiently resuscitated group (46 cases) and insufficiently resuscitated group (22 cases), the 2 groups’ heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), cardiac index (CI),stroke volume (SV),stroke volume index (SVI), acceleration index ( ACI ) ( systolic blood flow in the aorta of maximum acceleration ) , left ventricular ejection fraction (LVEF), peripheral resistance (SVR), peripheral resistance index (SVRI) (reflecting the peripheral vascular resistance), mortality rate were compared;analyzed the correlation between central venous oxygen saturation ( ScvO2 ) and hemodynamic parameters.Results Compared with treatment of 0 h, after 6 h EGDT treatment, patients’ CO, CI, SV, SVI, SVR, SVRI significantly increased, HR decreased significantly ( P <0.05) and LVEF, ACI without significant changes ( P >0.05).At initial of sufficiently resuscitated group, ScvO2 , Co, CI, SV, SVI, LVEF, ACI was significantly higher than that in the insuf-ficiently resuscitated group, CVP and SVR, SVRI was significantly lower than that of insufficiently resuscitated group ( P <0.05).Insufficiently resuscitated group’s mortality rate (72.7%) was significantly higher than that of sufficiently resuscita-ted group (41.3%) (χ2 =5.883, P <0.05).The Spearman correlation analysis showed that ScvO2 and CO, CI, SV, SVI were positively correlated ( r =0.670, r =0.717, r =0.581, r =0.568, P <0.05).Conclusion ICG monitoring system can guide the treatment of EGDT, improve the EGDT compliance rate, reduce the mortality rate.
Keywords：Septic shockImpedance cardiographyHemodynamic parametersEarly goal directed therapy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1147-1150 )