Clinical study on the treatment of pulmonary interstitial lesions in patients with systemic sclerosis by Shenmaikaifei powders
GUO Gang
LI Xiaojiao
LI Huiyun
ZHANG Haishun
ZHONG Qicheng
Abstract：Objective To observe the clinical effect of Shenmaikaifei powders for the treatment of pulmonary intersti-tial lesions in patients with systemic sclerosis.Methods From March 2010 to March 2014, 65 patients with systemic sclerosis and pulmonary interstitial lesions were randomly divided into treatment group and control group, 33 cases in treatment group and 32 cases in control group.2 groups were given conventional therapy, treatment group given Shenmaikaifei powders, con-trol group given roxithromycin, acetylcysteine effervescent tablets.12 weeks for 1 course.After a course of treatment, ob-served the curative effect of the two groups, and detected 2 groups'before and after treatment's TCM syndromes score, 6 mi-nutes walk distance (6MWT) , HRCT were used to observe lung ground glass like lesions, pulmonary function [ forced vital capacity ( FVC) , the forced expiratory volume in one second ( FEV1 ) , FEV1/FVC] improvement.Results Two groups had 30 cases in each group completed the experiment, treatment group's total effective rate was 93.33% (28/30), which was higher than that of the control group of 70.00% (21/30), the difference was statistically significant (χ2 =5.455, P <0.05).Compared with before treatment, after treatment in the two groups, TCM syndrome score, 6MWT, HRCT lungs glass like lesions, pulmonary function improvement were improved ( P <0.01 or P <0.05), and in the treatment group, shortness of breath, cough, TCM syndrome score, pulmonary function were better than those of the control group, the differences were statistically significant ( P <0.01 or P <0.05) .Conclusion Efficacy of the Shenmaikaifei powders for treatment of pulmo-nary interstitial lesions in patients with systemic sclerosis is good.
Keywords：Systemic sclerosisPulmonary interstitial lung diseaseShenmaikaifei powdersIntegrated traditional Chinese and western medicineTherapeutic effect
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1137-1140 )