Change of ankle brachial index and toe brachial index in type 2 diabetes mellitus and the correlation with diabetic foot

DING Yaqin; WU Jian; SHAO Xiaohong; ZHU Chunling; XIE Xin; LIU Jibo; SHEN Xiaoyu; LU Kan

doi:10.3969/j.issn.1671-6450.2015.11.011

Abstract：Objective To investigate the changes of ankle brachial index ( ABI) and toe brachial index ( TBI) in patients with type 2 diabetes mellitus ( DM) and the correlation with diabetic foot ( DF) .Methods Retrospectively analyzed from January 2013 to December 2014 clinical data of 126 patients with type 2 DM, 95 cases among them ( group DF) were complicated with DF, and 31 cases ( group NDF) were not complicated with DF.ABI and TBI levels were detected in the 2 groups, and the risk factors of DF were analyzed by Logistic regression.Results Group DF and group NDF’ s type 2 DM, BMI, FPG and HbA1c, TC, TG, HDL-C, ABI and TBI showed statistically significant differences ( P <0.05); different Wagner classification of DM patients’ ABI and TBI showed statistically significant differences ( P <0.05), and along with the increase of Wagner classification, the abnormal rate of ABI and TBI were increased significantly, the number were signifi-cantly decreased ( P <0.05).Spearman rank correlation analysis showed that, ABI and TBI and Wagner classification had significant negative correlation ( r =-0.593, r =-0.604, P <0.05);ABI and TBI combined for detection, the sensitivity for diagnosis of DF (93.7%) was significantly higher than that of ABI (69.5%) and TBI (67.4%) along ( P <0.05);multi-factor non-conditional Logistic regression analysis showed that, HDL-C, ABI and TBI are DF protective factors ( P <0.05), duration of diabetes, HbA1c were the risk factors ( P <0.05).Conclusion It demonstrated that the TBI, ABI were significantly decreased in type 2 DM patients, and were closely related with the occurrence and severity of DF, the combina-tion ABI and TBI detection was helpful to improve the diagnostic sensitivity of DF.