A correlation study of micro inflammatory state and chronic kidney disease
ZHANG Shuangyan
ZHAO Xin
WANG Meihong
SANG Xiaohong
LI Suhua
Abstract：Objective To investigate the relationship between the state of inflammation and chronic kidney disease (CKD).Methods From December 2013 to August 2014, investigated population of Moyu County in Xinjiang Uygur ( n =3 418) , including 198 cases of patients with CKD,as the CKD group;health examination of 1 512 cases, and randomly se-lected 194 healthy cases from them as the control group.Routine examination of all subjects, questionnaire survey and deter-mination of IL-6 and TNF-alpha, TGF-beta, hs-CRP inflammatory markers were performed.Results In the CKD group, body mass, waist circumference, hip circumference, TG, TC, DBP, SBP, BMI were higher than those of healthy control group, the difference was statistically significant ( P <0.05),eGFR was lower than that of the normal control group ( P <0.05). CKD group’ s IL-6, hs-CRP, TNF-alpha, TGF-beta level were higher than those in healthy control group, the differences were statistically significant ( P <0.05).Correlation analysis showed that eGFR was negatively correlated with IL-6,body weight and BMI in CKD group( B =-0.082,-1.540,3.688, P <0.05).Conclusion The levels of serum hs-CRP, IL-6 and TNF-alpha, TGF-beta and inflammatory cytokines may be involved in the occurrence and development of chronic kidney dis-ease, so control body weight, improve metabolism, control blood pressure, monitor and mitigate micro inflammatory level to improve the prognosis of patients with CKD also has important significance.
Keywords：Kidney diseasechronicInflammatory factorMicro inflammatory response
Publication Date：2015-01-01
Pages：4( 1129-1131,1132 )