The changes of tracheal wall thickness and serum inflammatory factors in patients with obstructive sleep apnea hy-popnea syndrome treated by BiPAP
WANG Zhen
JIN Xiaoyan
ZENG Jian
PAN Jing
Abstract：Objective To investigate the changes of tracheal wall thickness and serum inflammatory factors in pa-tients with obstructive sleep apnea hypopnea syndrome ( OSAHS) treated by BiPAP.Methods Selected from January 2013 to December 2013, patients with OSAHS of 42 cases, before and after treatment, using magnetic resonance (MR) to determine pharyngeal wall thickness as well as the soft palate tissue, collected blood samples of serum markers, these indices were meas-ured and compared.Results After treatment, patients'pharyngeal tissue thickness were improved, the posterior soft palate wall thickness was improved to (8.21 ±2.54) mm, the lingual region reduced to (9.18 ±3.26) mm, epiglottis region re-duced to (5.17 ±1.73) mm, and the lateral pharyngeal soft palate wall thickness was improve to (2.67 ±1.25) mm, tongue area reduced to (0.82 ±0.53) mm, epiglottis region reduced to (1.96 ±0.75) mm, compared with before treatment, the differences were statistically significant ( t =2.372, t =7.997, t =5.570, t =4.349, t =7.770, t =7.796, P <0.05) ;after treatment, patients'soft palate tissues improved, which area is shortened to (324.58 ±23.54) mm2 , the thickness was reduced to (10.76 ±1.52) mm, length was (28.36 ±3.58) mm, compared with before treatment, the difference was statis-tically significant ( t =14.006, t =3.507, t =6.555, P <0.05).After treatment, serum mark CRP reduced to (6.62 ± 1.74) g/L, IL-6 upgraded to (2.58 ±1.37 )ng/L, and 8 ISO prostaglandin improved to (37.36 ±8.74) ng/L, and nitro tyrosine reduced to (0.42 ±0.19 ) ng/L, compared with before treatment, the difference is statistically significant ( t =4.474, t =2.208, t =18.788, t =16.052, P <0.05).Conclusion Obstructive sleep apnea hypopnea syndrome can lead to a significant increase in the thickness of the airway wall, the indicators of the palate and serum inflammatory factors.
Keywords：Obstructive sleep apnea hypopnea syndromeTracheal wall thicknessSoft palateInflammatory markers
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1115-1117,1121 )