The relationship of the levels of LDL-C, Hcy, Npt, CRP and atherosclerosis in patients with acute cerebral infarc-tion
YANG Xiai
GONG Jiaming
LIU Yi
ZHAO Xue
HU Derong
Abstract：Objective To investigate acute cerebral infarction ( ACI) patients of low density lipoprotein cholesterol (LDL-C), homocysteine (Hcy) and neopterin (Npt), C-reactive protein (CRP) levels and their relationships with carotid atherosclerosis.Methods From June 2014 to June 2015, 68 cases of ACI dead patients as ACI group, selected the same pe-riod in the hospital for health examination's 60 cases of healthy control as control group, two groups of carotid artery intima-media thickness ( IMT) by Doppler ultrasound were measured, ELISA method were used for the determination of 2 groups'plasma Hcy and Npt, direct enzymatic were used to measure plasma LDL-C, immuno latex turbidimetric method were used to measure CRP.Results ACI patients'carotid artery plaque incidence rate was 91.17%, significantly higher than that in the healthy control group (10.00%, P <0.05), ACI group's the plasma level of LDL-C was (4.98 ±0.89) mmol/L, Hcy was (38.96 ±4.89) mol/L Npt was (2.45 ±0.48) ng/ml, CRP was (6.89 ±0.48) mg/L, which were higher than that in the healthy control group (2.86 ±0.93) mmol/L, (18.02 ±3.88) μmol/L, (1.38 ±0.59) ng/ml, (1.58 ±0.56) mg/L, and carotid artery IMT (1.85 ±0.32) mm was greater than that in the healthy control group (0.42 ±0.16) mm, the differences were statistically significant ( P <0.05).ACI patients'soft spot subgroups, mixed plaque subgroups'plasma LDL-C, Hcy, Npt and CRP levels were significantly higher than those of the hard plaque subgroups ( P <0.05).By Pearson univariate analysis, plasma LDL-C, Hcy, Npt, CRP and IMT was positively correlated ( r =0.412, r =0.326, r =0.345, r =0.369, P <0.05).Conclusion ACI with Carotid plaque instability of plasma LDL-C, Hcy, Npt, CRP levels were significantly higher than the unstable plaque group, suggesting that plasma LDL-C, Hcy, Npt, CRP levels may reflect the level of the ca-rotid artery in patients with ACI atherosclerosis stability.
Keywords：Cerebral infarctionacuteLow density lipoprotein cholesterolHomocysteineNeopterinC reactive pro-teinIntima-media thickness
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1111-1114 )