Application of cefuroxime combined Tanreqing in treatment of elderly patients with chronic bronchitis and its effect on blood gas and inflammatory factors

ZHANG Minghua; SHUI Mingming; YAO Jun; LIU Bicui

doi:10.3969/j.issn.1671-6450.2015.10.011

Abstract：Objective To study the effects of cefuroxime combined Tanreqing in treatment of elderly patients with chronic bronchitis and its effect on blood gas and inflammatory factors .Methods From April 2013 to June 2014 ,184 cases of elderly patients with chronic bronchitis , according to the order of admission patients were divided into observation group ( 92 cases) and control group (92 cases).All patients were given cefuroxime treatment , and the observation group patients were given Tanreqing on the basis of cefuroxime .Compared the clinical efficacy of the two groups of patients after treatment .Pulmo-nary rales improvement time and improvement of dyspnea time , as well as improvement of cough time were compared after treatment.Changes in blood gas and inflammatory factors were analyzed before and after treatment in the two groups of pa -tients.Results The overall effective rate in observation group (93.48%) was significantly higher than the control group (80.43%), the difference was statistically significant ( P <0.05).The patient's cough improve time (3.1 ±0.4) d, dysp-nea improve time (3.2 ±0.8) d and improve lung auscultation time (2.8 ±0.6) d obviously shorter than the control group , which were (4.8 ±1.8)d, (5.1 ±1.9)d and(4.9 ±2.3) d respectively,the difference was a statistically significance ( P <0.05).Compared with those before treatment, PaCO2, PaO2, CaO2 and serum CRP,IL-6,IL-8 in both groups were improved significantly,treatment group improved better than the control group ( P <0.05).Conclusion Apply cefuroxime and Tanreqing treatment on the elderly patients with chronic bronchitis , which can significantly improve blood gas indicators and inflammatory factors levels , the efficacy is good , which should be popularized use .