Variation of sex hormone profile in male patients with obstructive sleep apnea hypopnea syndrome

ZENG Zhengyan; LIU Yashou; WU Haibo; KONG Fanyi; LIU Shixiang

doi:10.3969/j.issn.1671-6450.2015.10.010

Abstract：Objective To explore the changes of sex hormone levels in male patients with obstructive sleep apnea hy -popnea syndrome ( OSAHS) and to analyze the key factors of affecting sex hormone levels .Methods General information and clinical data of 85 male OSAHS patients ( OSAHS group ) who were treated from March 2014 to March 2015 were collected . All patients underwent multichannel monitoring of sleep , and rapid eye movement ( REM) sleep in total sleep time ’ s ratio (REM%), apnea saturation (MSaO2) and average artery of hypopnea index (AHI), minimum arterial oxygen saturation (LSaO2) of the oxygen and Epworth Sleepiness Scale (ESS) were recorded, we collected 20 cases of age matched healthy male subjects as healthy control group .Differences of sex hormone levels were compared between the two groups , and the use of multiple linear regression model to analyze the correlation between age , BMI, REM%, AHI, LSaO2 , MSaO2 and ESS and sex hormone.Results BMI of OSAHS group was significantly higher than those in healthy control group ( P <0.01), TT and E2 were significantly lower than healthy control group ( P <0.01), eliminated BMI potential effect on the hormone lev-els, TT in OSAHS group was still significantly higher than those in healthy control group ( P <0.01), and E2 differences be-tween the 2 groups were disappeared ( P >0.05).Multiple linear regression analysis showed that , age of patients and E2 showed significant negative correlation (β=-0.37, P <0.01);MSaO2 and TT (β=0.31, P =0.02) and E2 (β=0.93, P <0.01) showed a significant positive correlation , and other indicators of TT and E2 had no clear relationship.Conclusion OSAHS male patients’ TT and E2 levels were significantly lower than the normal population , E2’s reduction may be associated with obesity, and TT’s reduce maybe due to OSAHS itself, or OSAHS and synergistic effect of obesity .E2 levels’ decreased along with age increasing;E2 and TT levels were decreased with increasing the degree of hypoxia .