Effects of recombinant human brain natriuretic peptide on cardiac function and ventricular remodeling in acute myo-cardial infarction patients with heart failure
QIN Zhong
ZHU Hai
ZHOU Jun
Abstract：Objective To investigate the effect of recombinant human brain natriuretic peptide ( rhBNP) in treatment of acute myocardial infarction (AMI) patients with heart failure, and its effect on cardiac function, ventricular remodeling. Methods From January 2013 to January 2015, 86 patients with heart failure were divided into 2 groups according to the ran-dom number table , 43 cases in each group .In the observation group , after coronary stent implantation , rhBNP intravenous in-jection was performed , control group with intravenous infusion of sodium nitroprusside and nitroglycerin .Observed the thera-peutic effect of the 2 groups , the change of heart function and ventricular remodeling after treatment .Results In the observa-tion group, the total efficiency was 86.05%, which was higher than that of the control group ’s 65.12%(χ2 =5.235, P <0.05), and compared with before treatment , 2 groups after the treatment ’s left ventricular diameter shortening ratio (LVFS), left ventricular ejection fraction (LVEF) were significantly increased ( P <0.05), left ventricular end diastolic diameter (LVEDD), relaxation time (IVRT), left ventricular posterior wall thickness (LVPWT) and septal thickness (IVST), left ventricular mass index(LVMI) and left ventricular remodeling index was significantly reduced ( P <0.05), and in the treat-ment group, these indexes were better than in the control group ( P <0.05).Conclusion It demonstrated that the rhBNP for treatment of AMI with heart failure was effective , it could effectively improve the patient's heart function , inhibit ventricular re-modeling , which is suitable for clinical promotion .
Keywords：Recombinant human brain natriuretic peptideMyocardial infarctionacuteHeart failureCardiac func-tionVentricular remodeling
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1000-1002 )