Analysis of platelet inhibition in stable angina pectoris patients complicated with hyperhomocystinemia after PCI
HUANG Ji
QIAN Haiyan
LI Zhao
WANG Qian
ZHANG Donghua
LI Nan
ZHANG Jingmei
LI Zhizhong
Abstract：Objective To analysis the effect of homocysteine levels on the detection of the patients with stable angina pectoris after PCI .Methods Randomly selected Beijing Anzhen Hospital and Fuwai Hospital from 2011 January to 2013 De-cember 450 coronary interventional patients , according to whether with high homocysteine hyperlipidemia or not , patients were divided into high homocysteine hyperlipidemia group ( n =138) and normal cysteine groups ( n =312), 2 groups of patients underwent the preoperative examination , drug therapy and coronary artery stent implantation , after admission , they underwent routine examination and thrombosis elastic graph detection .Analysis the index of the blood clots ’ differences between the 2 groups.Results High homocysteine group’s male patients ’ ratio, age, body weight, smoking, hypertension, low density lip-oprotein cholesterol , high density fat cholesterol ,left ventricular ejection fraction , hypersensitive C-reactive protein were sig-nificantly higher than that of normal homocysteine cysteine groups ( P <0.05).Multivariate regression analysis showed that , after control the various factors , statistically significant difference between and hyperhomocysteinemia and diphosphate adeno -sine inhibition rate were still existed (r =0.889, P =0.000).Two groups of patients’ thromboelastography’s main parame -ters, including the R value, value K, alpha angle, and thrombosis of the maximum amplitude (MA) showed significant differ-ences ( P <0.05); arachidonic acid (AA ) inhibition rate’s difference was not statistically significant ( P =0.072) and adenosine diphosphate( ADP) inhibition rate in the two groups had significant statistical differences ( P =0.000);and high homocysteine clopidogrel resistance was significantly higher than that of the normal homocysteine cysteine groups (26 a.8%vs. 16.1%, P =0.022).Conclusion Patients with stable angina pectoris with high homocysteine showed a high level of coagu -lation, and the incidence of clopidogrel resistance was high , suggesting that the need to strengthen anti platelet therapy after coronary intervention to reduce cardiovascular events .
Keywords：Stable angina pectorisPercutaneous coronary interventionHyperhomocystinemiaThromboelastographyArachidonic acid inhibition rateAdenosine diphosphate inhibition rate
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 991-995 )