Effect of high flux and conventional hemodialysis on chronic renal failure uremia patients
CHEN Yuqiong
WANG Juan
FANG Hua
ZHONG Jie
Abstract：Objective To compare the clinical efficacy of high flux hemodialysis ( HFHD) and conventional hemodi-alysis (HD) treatment for chronic renal failure and uremia .Methods From June 2012 to June 2013, 88 patients with chronic renal failure and uremia were randomly divided into HFHD group and HD group , each group with 44 cases.The two kinds of dialysis modality’s clinical efficacy were compared, blood urea nitrogen (BUN), serum creatinine (SCr), urea clearance in-dex (KT/V),β2 microglobulin (β2-MG), hemoglobin (Hb), albumin (Alb), phosphorus (P), calcium (Ca) and hemo-globin ( Hb) , albumin ( Alb) ,parathyroid hormone ( iPTH) and other indicators before and after the dialysis were compared , and adverse reactions in the two groups were observed .Results After 3 months of treatment , HFHD patients’ total effective rate was 95.5%(42/44), which was significantly higher than the 68.2%of HD group (30/44), the difference was statisti-cally significant (χ2 =9.517, P <0.05).Before treatment, the difference of serum BUN, SCr, and β2-MG, KT /V be-tween the two groups did not show statistically significant ( P >0.05);after treated for three months, the two groups’ BUN, SCr,β2-MG, KT/V were significantly improved compared with before treatment ( HFHD group:t =3.66, t =2.34, t =2.45, t =3.86;HD htoup:t =2.40, t =4.57, t =3.22, t =2.95, P <0.05), and the improvement of β2-MG, KT /V in HFHD group were better than HD group ( t =5.05, t =3.92, P <0.01);2 groups’ Hb, Alb, iPTH, Ca,P were signifi-cantly improved compared with before treatment ( HFHD group:t =5.88, t =2.41, t =3.81, t =3.21, t =6.66; HD group:t =2.94, t =3.32, t =2.81, t =4.11, t =2.40, P <0.05), after treatment, HFHD group’s P and iPTH were low-er than HD group ( t =7.09, t =2.39, P <0.05), Hb, Alb were higher than HD group ( t =4.16, t =3.91, P <0.01). HFHD group’s pruritus incidence was lower than the HD group (34.1%vs.56.8%,χ2 =4.583, P =0.032), the inci-dence of other dialysis-related complications did not show statistically significant differences ( P >0.05).Conclusion High flux hemodialysis uremia ’ s clinical efficacy is better than conventional hemodialysis , especially in clearing large , middle molecular toxins , and with no significant adverse reactions .
Keywords：HemodialysisHigh fluxUremiaRenal functionParathyroid hormone
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 932-935 )