The clinical efficacy of NIPPV assisted treatment for patients with severe bronchial asthma

YU Ranghui; WU Xiao-ning; FANG Yongguang

doi:10.3969/j.issn.1671-6450.2015.09.014

Abstract：Objective To observe the therapeutic value of noninvasive bi level positive pressure ventilation ( NIPPV) in patients with severe bronchial asthma .Methods From January 2012 to January 2014 , selected 60 patients with severe bronchial asthma , according to the random number table method , they were divided into the observation group and the control group with 30 cases in each group .The control group was treated with oxygen therapy plus medication , and the observation group was treated with NIPPV on the basis of treatment in the control group .The blood gas and pulmonary function before treatment and 1h, 12h, 24h, 72 h after treatment were compared , and followed up 3 months of the clinical effect .Results Compared with before treatment , 2 groups of patients 1h, 12, 24 h and 72 h after treatment, the pH, PaO2 and SaO2 gradually increased, PaCO2 gradually decreased ( P <0.05);observation group 1h, 12h, 24 h and 72 h after treatment’s pH, PaO2 and SaO2 were higher than those of the control group , and PaCO2 was lower than control group ( P <0.05).Compared with before treatment , after 1 week of treatment , patients in the two groups ’ FEV1 , FEV1/FVC and PEF were significantly in-creased ( P <0.05), and the observation group’s FEV1, FEV1/FVC and PEF were significantly increased than control group ( P <0.05).After 3 months of follow-up, the clinical curative effect of observation group was significantly better than the control group (93.33%vs.63.34%,χ2 =3.977, P <0.05).The incidence of complications between the 2 groups did not show significant differences (20.0% vs.10.0%, P >0.05).Conclusion Based on oxygen therapy and drug treatment , NIPPV can improve ventilation of patients with severe bronchial asthma and lung function with reliable clinical curative effect .